Evidence map›Paper›PMID 33419649›Full record

ReviewTrends in cell biology2021

Role of GTPases in Driving Mitoribosome Assembly.

Priyanka Maiti, Elena Lavdovskaia, Antoni Barrientos, Ricarda Richter-Dennerlein

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The late stages of yeast mitoribosome large subunit biogenesis.Biochimica et biophysica acta. Molecular cell research · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. A roadmap for ribosome assembly in human mitochondria.Nature structural & molecular biology · 2024
    Article
  11. Review
  12. Biallelic variants inmedRxiv : the preprint server for health sciences · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Mitoribosome Biogenesis.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  19. GTPase Era at the heart of ribosome assembly.Frontiers in molecular biosciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Priyanka MaitiDepartment of Neurology, University of Miami Miller School of Medicine, 1420 NW 9th Avenue, Neurology Research Building # 103B, Miami, FL 33136, USA.
Elena LavdovskaiaUniversity Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, D-37073 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, D-37075, Göttingen, Germany.
Antoni BarrientosDepartment of Neurology, University of Miami Miller School of Medicine, 1420 NW 9th Avenue, Neurology Research Building # 103B, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB # 2067, Miami, FL 33136, USA. Electronic address: abarrientos@med.miami.edu.
Ricarda Richter-DennerleinUniversity Medical Center Göttingen, Department of Cellular Biochemistry, Humboldtallee 23, D-37073 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, D-37075, Göttingen, Germany. Electronic address: ricarda.richter@med.uni-goettingen.de.

Funding

Mitochondrial Biogenesis in Health and DiseaseR35GM118141 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BARRIENTOS, ANTONI · 2016 to 2025
$8.9M
NIGMS NIH HHS R35 GM118141
6 · The paper itself

Abstract

Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we review recent progress in our understanding of mitoribosome assembly GTPases. We describe their shared and specific features and mechanisms of action, compare them with their bacterial counterparts, and discuss their possible roles in the assembly of small or large mitoribosomal subunits and the formation of the monosome by establishing quality-control checkpoints during these processes. Furthermore, following the recent unification of the nomenclature for the mitoribosomal proteins, we also propose a unified nomenclature for mitoribosome assembly GTPases.

Indexed as

GTP PhosphohydrolasesMitochondrial RibosomesRibosomal ProteinsMitochondriaMitochondrial ProteinsGTP PhosphohydrolasesMitochondrial ProteinsRibosomal ProteinsGTPBPmitochondrial diseasesmitochondrial ribosomemitoribosome assembly GTPaseOXPHOS deficiencyquality control of mitoribosome maturation

Identifiers

PMID33419649
PMCPMC7954922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.