Evidence map›Paper›PMID 33419395›Full record

ReviewBMC ophthalmology2021

Orbital aspergillosis: a case report and review of the literature.

Mael Lever, Benjamin Wilde, Roman Pförtner, Cornelius Deuschl, Oliver Witzke, Stefanie Bertram, Anja Eckstein, Peter-Michael Rath

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Lacrimal sac Aspergillosis Masquerading as Malignancy: A Rare Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  2. Article
  3. Eye fungal infections: a mini review.Archives of microbiology · 2023
    Review
  4. Article
  5. Article
  6. Necrotizing orbital infections: A comprehensive review.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mael LeverDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany. mael.lever@uk-essen.de.ORCID http://orcid.org/0000-0002-3244-6782
Benjamin WildeDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Roman PförtnerDepartment of Oral and Maxillofacial Surgery, Kliniken Essen Mitte, University Duisburg-Essen, Essen, Germany.
Cornelius DeuschlDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Oliver WitzkeDepartment of Infectious Diseases, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Stefanie BertramInstitute of Pathology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Anja EcksteinDepartment of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Peter-Michael RathInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DEEssen University Hospital · DEKliniken Essen-Mitte · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrbital aspergillosis is a rare sight- and life-threatening fungal infection affecting immunocompromised or otherwise healthy patients. It is often misdiagnosed due to its unspecific clinical and radiologic appearance. Therapeutic delay can have dramatic consequences. However, progress in microbiological diagnostic techniques and therapeutic experience from case series help improve the management of this disease. CASE PRESENTATION: A 78-year-old immunocompetent woman presented at an eye clinic for subacute swelling, reddening, and ptosis of her left upper eyelid. Based on radiologic and histologic considerations, she was treated for idiopathic orbital inflammation, but her condition worsened. After a second biopsy of the orbital mass, aspergillosis was diagnosed. Her condition improved promptly after initiation of an oral voriconazole treatment. Additionally, using a polymerase chain reaction (PCR) assay, A. fumigatus was identified on tissue of both biopsies and its azole susceptibility was examined simultaneously.

conclusionsIn the case described here, oral antifungal treatment was sufficient for the therapy of invasive orbital aspergillosis. Performing fungal PCR on orbital tissue can accelerate the diagnostic process and should be performed in ambiguous cases of slowly growing orbital mass. Finally, interdisciplinary management is the key to optimal treatment of orbital tumours and infections.

Indexed as

Antifungal AgentsAspergillosisVoriconazoleAgedAspergillus fumigatusFemaleHumansAntifungal AgentsVoriconazoleAspergillus spp.azole resistanceCase reportorbital tumourproptosis

Identifiers

PMID33419395
PMCPMC7792050
OpenAlexW3119983678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.