ArticleBiomedicines2020
Biocompatibility and Immune Response of a Newly Developed Volume-Stable Magnesium-Based Barrier Membrane in Combination with a PVD Coating for Guided Bone Regeneration (GBR).
Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Collagen Membrane Fixation Technique Affects Its Space Maintenance Capacity After Flap Closure: An Ex Vivo Analysis.Clinical oral implants research · 2026Article
- Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026Review
- Magnesium-Based Membrane for Alveolar Ridge Regeneration-A Scoping Review.Journal of functional biomaterials · 2026Review
- Research status and prospects of biodegradable magnesium-based metal guided bone regeneration membranes.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Review
- Guided Bone Regeneration Using a Novel Magnesium Membrane: A Literature Review and a Report of Two Cases in Humans.Journal of functional biomaterials · 2023Review
- Application of Biodegradable Magnesium Membrane Shield Technique for Immediate Dentoalveolar Bone Regeneration.Biomedicines · 2023Article
- Degradable Pure Magnesium Used as a Barrier Film for Oral Bone Regeneration.Journal of functional biomaterials · 2022Article
- Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review.The Japanese dental science review · 2022Review
- Preparation of functional poly-(lactic acid-co-glycolic acid)-based guided bone-regeneration membrane and its application in the reconstruction of mandibular defects in rats.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review.Polymers · 2022Review
- Editorial of the Special Issue: "Soft and Hard Tissue Regeneration".Biomedicines · 2022Article
- Advances in Barrier Membranes for Guided Bone Regeneration Techniques.Frontiers in bioengineering and biotechnology · 2022Review
- The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes.Materials (Basel, Switzerland) · 2021Article
- Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR).International journal of molecular sciences · 2021Article
- Research status of biodegradable metals designed for oral and maxillofacial applications: A review.Bioactive materials · 2021Review
- Granulocytes and their Involvement in the Foreign Body Response to Biomaterials and Tissue Repair.In vivo (Athens, Greece)Review
- Article
- Lymphocytes and their Involvement in the Foreign Body Response to Biomaterials and Tissue Repair.In vivo (Athens, Greece)Review
- Republication:In vivo (Athens, Greece)Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, there are no bioresorbable alternatives to non-resorbable and volume-stable membranes in the field of dentistry for guided bone or tissue regeneration (GBR/GTR). Even magnesium (Mg) has been shown to constitute a favorable biomaterial for the development of stabilizing structures. However, it has been described that it is necessary to prevent premature degradation to ensure both the functionality and the biocompatibility of such Mg implants. Different coating strategies have already been developed, but most of them did not provide the desired functionality. The present study analyses a new approach based on ion implantation (II) with PVD coating for the passivation of a newly developed Mg membrane for GBR/GTR procedures. To demonstrate comprehensive biocompatibility and successful passivation of the Mg membranes, untreated Mg (MG) and coated Mg (MG-Co) were investigated in vitro and in vivo. Thereby a collagen membrane with an already shown biocompatibility was used as control material. All investigations were performed according to EN ISO 10993 regulations. The in vitro results showed that both the untreated and PVD-coated membranes were not cytocompatible. However, both membrane types fulfilled the requirements for in vivo biocompatibility. Interestingly, the PVD coating did not have an influence on the gas cavity formation compared to the uncoated membrane, but it induced lower numbers of anti-inflammatory macrophages in comparison to the pure Mg membrane and the collagen membrane. In contrast, the pure Mg membrane provoked an immune response that was fully comparable to the collagen membrane. Altogether, this study shows that pure magnesium membranes represent a promising alternative compared to the nonresorbable volume-stable materials for GBR/GTR therapy.
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