Evidence map›Paper›PMID 33419257›Full record

ArticleInternational journal of molecular sciences2020

Ionic Environment Affects Biomolecular Interactions of Amyloid-β: SPR Biosensor Study.

Erika Hemmerová, Tomáš Špringer, Zdeňka Krištofiková, Jiří Homola

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erika HemmerováInstitute of Photonics and Electronics of the Czech Academy of Sciences, Chaberská 1014/57, 182 51 Prague, Czech Republic.
Tomáš ŠpringerInstitute of Photonics and Electronics of the Czech Academy of Sciences, Chaberská 1014/57, 182 51 Prague, Czech Republic.
Zdeňka KrištofikováNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic.
Jiří HomolaInstitute of Photonics and Electronics of the Czech Academy of Sciences, Chaberská 1014/57, 182 51 Prague, Czech Republic.ORCID 0000-0001-6258-015X
Czech Academy of Sciences, Institute of Photonics and Electronics · CZNational Institute of Mental Health · CZ

Funding

Grantová Agentura České Republiky 19-02739SGrantová Agentura České Republiky 20-23787X
6 · The paper itself

Abstract

In early stages of Alzheimer's disease (AD), amyloid beta (Aβ) accumulates in the mitochondrial matrix and interacts with mitochondrial proteins, such as cyclophilin D (cypD) and 17β-hydroxysteroid dehydrogenase 10 (17β-HSD10). Multiple processes associated with AD such as increased production or oligomerization of Aβ affect these interactions and disbalance the equilibrium between the biomolecules, which contributes to mitochondrial dysfunction. Here, we investigate the effect of the ionic environment on the interactions of Aβ (Aβ

Indexed as

17-Hydroxysteroid DehydrogenasesAlzheimer DiseaseAmyloid beta-PeptidesBiosensing TechniquesHumansIonsMitochondriaMitochondrial ProteinsPeptide FragmentsPeptidyl-Prolyl Isomerase FSurface Plasmon Resonance17-Hydroxysteroid Dehydrogenases3 (or 17)-beta-hydroxysteroid dehydrogenaseAmyloid beta-PeptidesIonsMitochondrial ProteinsPeptide FragmentsPeptidyl-Prolyl Isomerase F17β-hydroxysteroid dehydrogenase 10 (17β-HSD10)amyloid beta (Aβ)biomolecular interactionscyclophilin D (cypD)ionic environmentmitochondrial matrixsurface plasmon resonance (SPR)

Identifiers

PMID33419257
PMCPMC7766583
OpenAlexW3117599246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.