ArticleBrain sciences2021
Effects of Lifelong Musicianship on White Matter Integrity and Cognitive Brain Reserve.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Art, neuroplasticity, and tradition: a narrative review and conceptual perspective of Chinese woodblock printing in global art practices and Parkinson's disease neuroscience.Frontiers in neuroscience · 2026Review
- Developing an Equitable Machine Learning-Based Music Intervention for Older Adults At Risk for Alzheimer Disease: Protocol for Algorithm Development and Validation.JMIR research protocols · 2025Article
- Evolution of Oligodendroglia and Myelin.Advances in neurobiology · 2025Review
- Long-term training alters response dynamics in the aging auditory cortex.Hearing research · 2024Article
- The effects of musicality on brain network topology in the context of Alzheimer's disease and memory decline.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.PloS one · 2024Article
- Efferent Control in Musicians: A Review.Audiology research · 2023Review
- Musical experience prior to traumatic exposure as a resilience factor: a conceptual analysis.Frontiers in psychology · 2023Review
- Resting-state functional connectivity in lifelong musicians.Psychoradiology · 2023Article
- Editorial: The impact of physical activity on white matter during healthy aging.Frontiers in aging neuroscience · 2023Article
- Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia.Cells · 2022Review
- Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults.Frontiers in psychology · 2022Article
- White matter dementia then… and now.Frontiers in neurology · 2022Review
- Diffusion Kurtosis Imaging Fiber Tractography of Major White Matter Tracts in Neurosurgery.Brain sciences · 2021Article
- High-Resolution Nerve Ultrasound Abnormalities in POEMS Syndrome-A Comparative Study.Diagnostics (Basel, Switzerland) · 2021Article
- Neural Processing Underlying Executive Functions in Bilinguals: "Heads I Win, Tails You Lose".Frontiers in human neuroscience · 2021Article
- Decoding everyday levels of musical training from subcortical white-matter architecture.Imaging neuroscience (Cambridge, Mass.)Article
- Music Engagement as a Source of Cognitive Reserve.American journal of Alzheimer's disease and other dementiasReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
There is a significant body of research that has identified specific, high-end cognitive demand activities and lifestyles that may play a role in building cognitive brain reserve, including volume changes in gray matter and white matter, increased structural connectivity, and enhanced categorical perception. While normal aging produces trends of decreasing white matter (WM) integrity, research on cognitive brain reserve suggests that complex sensory-motor activities across the life span may slow down or reverse these trends. Previous research has focused on structural and functional changes to the human brain caused by training and experience in both linguistic (especially bilingualism) and musical domains. The current research uses diffusion tensor imaging to examine the integrity of subcortical white matter fiber tracts in lifelong musicians. Our analysis, using Tortoise and ICBM-81, reveals higher fractional anisotropy, an indicator of greater WM integrity, in aging musicians in bilateral superior longitudinal fasciculi and bilateral uncinate fasciculi. Statistical methods used include Fisher's method and linear regression analysis. Another unique aspect of this study is the accompanying behavioral performance data for each participant. This is one of the first studies to look specifically at musicianship across the life span and its impact on bilateral WM integrity in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.