Evidence map›Paper›PMID 33419226›Full record

ArticleInternational journal of molecular sciences2021

Reduced Graphene Oxides Modulate the Expression of Cell Receptors and Voltage-Dependent Ion Channel Genes of Glioblastoma Multiforme.

Jaroslaw Szczepaniak, Joanna Jagiello, Mateusz Wierzbicki, Dorota Nowak, Anna Sobczyk-Guzenda, Malwina Sosnowska, Slawomir Jaworski, Karolina Daniluk, Maciej Szmidt, Olga Witkowska-Pilaszewicz and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Carbon-Based Nanomaterials.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jaroslaw SzczepaniakDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.ORCID 0000-0001-5808-9755
Joanna JagielloDepartment of Chemical Synthesis and Flake Graphene, Łukasiewicz Research Network-Institute of Microelectronics and Photonics, 01-919 Warsaw, Poland.
Mateusz WierzbickiDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.ORCID 0000-0003-3623-8929
Dorota NowakTricomed SA, 5/9 Swientojanska St., 93-493 Lodz, Poland.
Anna Sobczyk-GuzendaInstitute of Materials Science and Engineering, Lodz University of Technology, 90-924 Lodz, Poland.ORCID 0000-0003-1583-4238
Malwina SosnowskaDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Slawomir JaworskiDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Karolina DanilukDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Maciej SzmidtDepartment of Morphologic Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Olga Witkowska-PilaszewiczDepartment of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.ORCID 0000-0002-3541-5914
Barbara Strojny-CieslakDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.ORCID 0000-0002-2642-5491
Marta GrodzikDepartment of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.ORCID 0000-0001-5359-1885
Warsaw University of Life Sciences · PLLodz University of Technology · PLŁukasiewicz Research Network · PLTricomed (Poland) · PL

Funding

Narodowe Centrum Badań i Rozwoju LIDER/144/L-6/14/NCBR/2015
6 · The paper itself

Abstract

The development of nanotechnology based on graphene and its derivatives has aroused great scientific interest because of their unusual properties. Graphene (GN) and its derivatives, such as reduced graphene oxide (rGO), exhibit antitumor effects on glioblastoma multiforme (GBM) cells in vitro. The antitumor activity of rGO with different contents of oxygen-containing functional groups and GN was compared. Using FTIR (fourier transform infrared) analysis, the content of individual functional groups (GN/exfoliation (ExF), rGO/thermal (Term), rGO/ammonium thiosulphate (ATS), and rGO/ thiourea dioxide (TUD)) was determined. Cell membrane damage, as well as changes in the cell membrane potential, was analyzed. Additionally, the gene expression of voltage-dependent ion channels (

Indexed as

Cell Line, TumorCellsChloride ChannelsGene Expression Regulation, NeoplasticGlioblastomaGraphiteHumansIon ChannelsMembrane PotentialsMembrane ProteinsMicroscopy, Electron, ScanningOxidation-ReductionPotassium Channels, Voltage-GatedReceptors, Cell SurfaceRNA, MessengerSpectroscopy, Fourier Transform InfraredChloride ChannelsClC-3 channelgraphene oxideGraphiteIon ChannelsKCNE4 protein, humanMembrane ProteinsNALCN protein, humanPotassium Channels, Voltage-GatedReceptors, Cell SurfaceRNA, Messengercell membrane receptorglioblastoma multiformegraphenemembrane potentialreduced graphene oxidevoltage-gated ion channel

Identifiers

PMID33419226
PMCPMC7825604
OpenAlexW3121127326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.