Evidence map›Paper›PMID 33419138›Full record

ArticleInternational journal of environmental research and public health2021

Cost of Venous Thromboembolic Disease in Patients with Lung Cancer: Costecat Study.

Ana Rosa Rubio-Salvador, Vicente Escudero-Vilaplana, José Antonio Marcos Rodríguez, Irene Mangues-Bafalluy, Beatriz Bernárdez, Carlos García Collado, Roberto Collado-Borrell, María Dolores Alvarado Fernández, José Ignacio Chacón López-Muñiz, María Yébenes Cortés and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Impact of Pregnancy-Related Venous Thromboembolism on Quality of Patients' Lives.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Ana Rosa Rubio-SalvadorServicio de Farmacia, Complejo Hospitalario de Toledo, 45007 Toledo, Spain.
Vicente Escudero-VilaplanaServicio de Farmacia, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
José Antonio Marcos RodríguezServicio de Farmacia, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain.
Irene Mangues-BafalluyServicio de Farmacia, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain.
Beatriz BernárdezServicio de Farmacia, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, 15706 A Coruña, Spain.ORCID 0000-0001-6579-4903
Carlos García ColladoServicio de Farmacia. Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.ORCID 0000-0002-8270-2123
Roberto Collado-BorrellServicio de Farmacia, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
María Dolores Alvarado FernándezServicio de Farmacia, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain.
José Ignacio Chacón López-MuñizServicio de Oncología Médica, Complejo Hospitalario de Toledo, 45007 Toledo, Spain.
María Yébenes CortésPharmacoeconomics & Outcomes Research Iberia, 28224 Madrid, Spain.
Manuel Gómez BarreraPharmacoeconomics & Outcomes Research Iberia, 28224 Madrid, Spain.
Miguel Ángel Calleja-HernándezServicio de Farmacia, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain.
Hospital Universitario Virgen Macarena · ESComplejo Hospitalario Universitario de Toledo · ESHospital General Universitario Gregorio Marañón · ESPharmacoeconomics and Health Outcomes Research Iberia (Spain) · ESComplejo Hospitalario Universitario de Santiago · ESHospital Universitari Arnau de Vilanova · ESHospital Universitario Virgen de las Nieves · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with lung cancer (LC) are at significantly higher risk of developing venous thromboembolism (VTE), which may lead to increased use of health resources and the cost of management. The main aim of the study was to determine the cost of the management of VTE events in patients with LC treated with Low Molecular Weight Heparins (LMWH) in Spain.

methodsCostecat was an, observational, ambispective pharmacoeconomic study. Patients with LC, with a first episode of VTE (symptomatic or incidental) in treatment with LMWH, were recruited from six third-level hospitals and followed up for six months. Sociodemographic, clinical and resource use variables of VTE-related implications and its treatment were collected. Direct healthcare costs and direct non-healthcare costs were recorded. Data collection was documented in an electronic case report. Unit costs were obtained from national databases. Costs (€2018) were estimated from the healthcare perspective. Statistical analysis was performed using the statistical program R 3.4.3 version (30 November 2017).

resultsForty-seven patients were included. Mean age was 65.4 years, 66.0% were male. The percentage of patients with LC who had metastatic disease was 78.7%. Twenty-three patients (48.9%) needed hospital admissions due to thromboembolic episode. Total average cost of patients with cancer associated VTE (CAT) was €109,696.6 per patient/semester. The hospitalizations represent 65.8% of total costs (7207.3 € SD 13,996.9 €), followed by LMWH therapy which represents 18.6% (2033.8 € SD:630.5 €).

conclusionsVenous thromboembolism episodes induce an economic impact on patients and healthcare systems. Direct healthcare costs are the major burden of the total cost, in which hospitalizations are the main drivers of cost.

Indexed as

Lung NeoplasmsVenous ThrombosisAnticoagulantsFemaleHeparin, Low-Molecular-WeightHumansMaleSpainAnticoagulantsHeparin, Low-Molecular-Weightcancercosteconomic impactLMWHthromboembolic disease

Identifiers

PMID33419138
PMCPMC7825488
OpenAlexW3120080157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.