ArticlePlants (Basel, Switzerland)2021
Metabolome Analysis Revealed the Mechanism of Exogenous Glutathione to Alleviate Cadmium Stress in Maize (
Article in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Cadmium tolerance mediated by GhBCAT12 through branched-chain amino acid degradation via vacuolar sequestration in cotton.Stress biology · 2026Article
- Transcriptomic and metabolomic profiling to unravel sex-dependent mechanisms and the role of exogenous glutathione in Marchantia polymorpha under cadmium stress.BMC plant biology · 2026Article
- Trichoderma genome and multiomics insight into promoting yield and reducing grain cadmium in barley and wheat.Journal of integrative plant biology · 2026Article
- Iron-modified biochar modulates root metabolism, mitigates antimony accumulation and enhances growth in rice (Oryza sativa).BMC plant biology · 2025Article
- Transcriptomic and metabolomic analyses of Tartary buckwheat roots during cadmium stress.Scientific reports · 2025Article
- Mitigation mechanism of silicon and iron co-application to cadmium toxicity in tomato seedlings by integrated transcriptomic and physiological correlation analysis.Frontiers in plant science · 2025Article
- Physiological and biochemical responses in a cadmium accumulator of traditional Chinese medicine Ligusticum sinense cv. Chuanxiong under cadmium condition.Stress biology · 2024Article
- Cadmium Stress Signaling Pathways in Plants: Molecular Responses and Mechanisms.Current issues in molecular biology · 2024Review
- Cadmium negatively affects the growth and physiological status and the alleviation effects by exogenous selenium in silage maize (Zea mays L.).Environmental science and pollution research international · 2024Article
- The Influence of Cadmium on Fountain Grass Performance Correlates Closely with Metabolite Profiles.Plants (Basel, Switzerland) · 2023Article
- Antioxidant Potential of Glutathione and Crosstalk with Phytohormones in Enhancing Abiotic Stress Tolerance in Crop Plants.Plants (Basel, Switzerland) · 2023Review
- Genome-wide identification and expression pattern analysis of R2R3-MYB transcription factor gene family involved in puerarin biosynthesis and response to hormone in Pueraria lobata var. thomsonii.BMC plant biology · 2023Article
- Analysis of the mechanism of Ricinus communis L. tolerance to Cd metal based on proteomics and metabolomics.PloS one · 2023Article
- Using Exogenous Melatonin, Glutathione, Proline, and Glycine Betaine Treatments to Combat Abiotic Stresses in Crops.International journal of molecular sciences · 2022Review
- Versatile roles of sorbitol in higher plants: luxury resource, effective defender or something else?Planta · 2022Review
- Exogenous Hemin alleviated cadmium stress in maize (Frontiers in plant science · 2022Article
- An amino acid fertilizer improves the emergent accumulator plantFrontiers in plant science · 2022Article
- Mitigation of Environmental Stress-Impacts in Plants: Role of Sole and Combinatory Exogenous Application of Glutathione.Frontiers in plant science · 2021Review
- Ovary Abortion Induced by Combined Waterlogging and Shading Stress at the Flowering Stage Involves Amino Acids and Flavonoid Metabolism in Maize.Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Cadmium (Cd) is one of the major heavy metal pollutants in the environment and imposes severe limitations on crop growth and production. Glutathione (GSH) plays an important role in plant Cd tolerance which is able to scavenge stresses-induced reactive oxygen species (ROS) and is involved in the biosynthesis of phytochelatins (PCs). Our previous study revealed that Cd stress affects maize growth, and the GSH treatment could relieve Cd stress in maize seedlings. In this study, we attempted to characterize the metabolomics changes in maize leaves and roots under Cd stress and exogenous GSH conditions. We identified 145 and 133 metabolites in the leaves and roots, respectively. Cd stress decreased the tricarboxylic acid cycle (TCA cycle) metabolism and increased the amino acid contents in the leaves, while it decreased the amino acid contents, increased the TCA cycle metabolism, the sugar contents, and shikimic acid metabolism in the roots. On the other hand, exogenous GSH increased the GSH content, changed the production of metabolites related to antioxidant systems (such as ascorbic acid-related metabolites and flavonoid-related metabolites), and alleviated lipid peroxidation, thereby alleviating the toxic effect of Cd stress on maize. These findings support the idea that GSH alleviates Cd-induced stress in maize and may help to elucidate the mechanism governing Cd-induced stress and the GSH-driven alleviation effect.
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