Evidence map›Paper›PMID 33419017›Full record

ArticleInternational journal of molecular sciences2021

Tetraoctylammonium, a Long Chain Quaternary Ammonium Blocker, Promotes a Noncollapsed, Resting-Like Inactivated State in KcsA.

Ana Marcela Giudici, Clara Díaz-García, Maria Lourdes Renart, Ana Coutinho, Manuel Prieto, José M González-Ros, José Antonio Poveda

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Membrane Proteins: Structure, Function and Motion.International journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ana Marcela GiudiciInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, E-03202 Elche, Spain.
Clara Díaz-GarcíaInstitute for Bioengineering and Bioscience (IBB), Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.ORCID 0000-0001-8927-3600
Maria Lourdes RenartInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, E-03202 Elche, Spain.ORCID 0000-0002-6717-4756
Ana CoutinhoInstitute for Bioengineering and Bioscience (IBB), Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.ORCID 0000-0003-1653-0703
Manuel PrietoInstitute for Bioengineering and Bioscience (IBB), Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.ORCID 0000-0003-3012-6598
José M González-RosInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, E-03202 Elche, Spain.
José Antonio PovedaInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, E-03202 Elche, Spain.ORCID 0000-0003-0722-3752
Universitat de Miguel Hernández d'Elx · ESUniversity of Lisbon · PT

Funding

European Regional Development Fund PGC2018-093505-B-I00Fundação para a Ciência e a Tecnologia UIDB/04565/2020Medical Biochemistry and Biophysics Doctoral Programme SFRH/PD/BD/135154/2017Ministerio de Ciencia e Innovación PGC2018-093505-B-I00
6 · The paper itself

Abstract

Alkylammonium salts have been used extensively to study the structure and function of potassium channels. Here, we use the hydrophobic tetraoctylammonium (TOA

Indexed as

Bacterial ProteinsBinding SitesFluorescence Resonance Energy TransferHydrogen-Ion ConcentrationMutagenesis, Site-DirectedPotassiumPotassium ChannelsProtein StabilityProtein Structure, TertiaryQuaternary Ammonium CompoundsSodiumTemperatureBacterial ProteinsPotassiumPotassium Channelsprokaryotic potassium channelQuaternary Ammonium CompoundsSodiumbinding affinityC-type inactivationhomo-FRETpotassium channelsprotein thermal stabilityselectivity filter conformationsteady-state and time-resolved fluorescence anisotropytetraalkylammonium salts

Identifiers

PMID33419017
PMCPMC7825302
OpenAlexW3119452477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.