Evidence map›Paper›PMID 33418983›Full record

ArticleCancers2021

The Prognostic Value of Lymph Node Involvement after Neoadjuvant Chemotherapy Is Different among Breast Cancer Subtypes.

Lucie Laot, Enora Laas, Noemie Girard, Elise Dumas, Eric Daoud, Beatriz Grandal, Jean-Yves Pierga, Florence Coussy, Youlia Kirova, Elsy El-Alam and 5 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lucie LaotDepartment of Surgical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Enora LaasDepartment of Surgical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Noemie GirardDepartment of Surgical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Elise DumasResidual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, INSERM, University Paris, 75005 Paris, France.ORCID 0000-0002-7877-719X
Eric DaoudResidual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, INSERM, University Paris, 75005 Paris, France.ORCID 0000-0003-4556-0856
Beatriz GrandalResidual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, INSERM, University Paris, 75005 Paris, France.
Jean-Yves PiergaDepartment of Medical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Florence CoussyDepartment of Medical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Youlia KirovaDepartment of Radiotherapy, Institute Curie, University Paris, 75005 Paris, France.
Elsy El-AlamDepartment of Tumor Biology, Institute Curie, University Paris, 75005 Paris, France.
Guillaume BataillonDepartment of Tumor Biology, Institute Curie, University Paris, 75005 Paris, France.
Marick LaeHenri Becquerel Cancer Center, Department of Pathology, INSERM U1245, UniRouen Normandy University, 76130 Rouen, France.
Florence LlouquetDepartment of Surgical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Fabien ReyalDepartment of Surgical Oncology, Institute Curie, University Paris, 75005 Paris, France.
Anne-Sophie HamyResidual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, INSERM, University Paris, 75005 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe three different breast cancer subtypes (Luminal,

methodsWe retrospectively evaluated the axillary involvement (0, 1 to 3 positive nodes, ≥4 positive nodes) on surgical specimens from a cohort of T1-T3NxM0 BC patients treated with NAC between 2002 and 2012. We analyzed the association between nodal involvement (ypN) binned into three classes (0; 1 to 3; 4 or more), relapse-free survival (RFS) and overall survival (OS) among the global population, and according to BC subtypes.

results1197 patients were included in the analysis (luminal (

conclusionThe prognostic value of residual axillary disease should be considered differently in the 3 BC subtypes to accurately stratify patients with a high risk of recurrence after NAC who should be offered second line therapies.

Indexed as

breast cancerneoadjuvant chemotherapynodal involvementnumber of positive nodesprognosticresidual axillary disease

Identifiers

PMID33418983
PMCPMC7825348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.