ArticleInternational journal of environmental research and public health2021
Survival Outcomes and Predictors for Patients who Failed Chemoradiotherapy/Radiotherapy and Underwent Salvage Total Laryngectomy.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better?Virchows Archiv : an international journal of pathology · 2025Review
- Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery.Scientific reports · 2025Article
- Clinical Relevance of Resection Margins in Patients with Total Laryngectomy or Laryngopharyngectomy.Cancers · 2024Article
- Prognostic Value of Pathologically Positive Nodal Number in p16-Negative Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma with pN3b Status.Diagnostics (Basel, Switzerland) · 2022Article
- The Prognostic Value of Preoperative Albumin-to-Alkaline Phosphatase Ratio on Survival Outcome for Patients With Locally Advanced Oral Squamous Cell Carcinoma.Technology in cancer research & treatmentArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundTo assess the presence of adverse pathological features at the time of salvage total laryngectomy (TL) associated with oncologic outcome.
methodsNinety patients with persistent/locally recurrent disease and who subsequently underwent salvage TL after definitive treatment by radiation alone (RTO) or concurrent chemo-radiation (CCRT) from 2009 to 2018 were retrospectively enrolled. Kaplan-Meier methods were used to estimate overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS).
resultsLymphovascular invasion (LVI), perineural invasion, positive margin, and stage IV disease were associated with worse survival in the univariate analysis. In the multivariate analysis, the presence of LVI and positive margin were both independent negative predictors in OS (LVI: adjusted hazard ratio (aHR) = 2.537, 95% CI: 1.163-5.532,
conclusionsThe presence of LVI and positive margin were both associated with poor OS, DSS, and DFS among patients who underwent salvage TL after failure of RTO/CCRT. The role of adjuvant therapy for high-risk patients after salvage TL to improve the chance of survival requires more investigation in the future.
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