Evidence map›Paper›PMID 33418916›Full record

ArticleInternational journal of environmental research and public health2021

Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice.

Marcus M Lawrence, Kevin A Zwetsloot, Susan T Arthur, Chase A Sherman, Joshua R Huot, Vladimir Badmaev, Mary Grace, Mary Ann Lila, David C Nieman, R Andrew Shanely

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Marcus M LawrenceDepartment of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA.
Kevin A ZwetslootDepartment of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA.
Susan T ArthurLaboratory of Systems Physiology, Department of Kinesiology, University of North Carolina Charlotte, Charlotte, NC 28223, USA.
Chase A ShermanDepartment of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA.
Joshua R HuotLaboratory of Systems Physiology, Department of Kinesiology, University of North Carolina Charlotte, Charlotte, NC 28223, USA.
Vladimir BadmaevAmerican Medical Holdings Inc., Staten Island, NY 10314, USA.
Mary GracePlants for Human Health Institute, North Carolina Research Campus, North Carolina State University, Kannapolis, NC 28081, USA.
Mary Ann LilaPlants for Human Health Institute, North Carolina Research Campus, North Carolina State University, Kannapolis, NC 28081, USA.ORCID 0000-0002-4928-3836
David C NiemanHuman Performance Laboratory, North Carolina Research Campus, Kannapolis, NC 28081, USA.ORCID 0000-0002-8305-1860
R Andrew ShanelyDepartment of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA.ORCID 0000-0002-1916-3809
University of North Carolina at Charlotte · USAppalachian State University · USDavid H. Murdock Research Institute · USNorth Carolina State University · USAmerican Medical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle mass and strength are lost with aging. Phytoecdysteroids, in particular 20-hydroxyecdysone (20E), increase protein synthesis in C2C12 skeletal muscle cells and muscle strength in young rats. The objective of this study was to determine whether an extract from

Indexed as

Anabolic AgentsAgingAnimalsMaleMiceMice, Inbred C57BLMuscle, SkeletalPhosphatidylinositol 3-KinasesRatsAnabolic AgentsPhosphatidylinositol 3-Kinases20-hydroxyecdysoneAktatrogeneshypertrophyp70S6Kskeletal muscle

Identifiers

PMID33418916
PMCPMC7825148
OpenAlexW3120597837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.