ArticleBioengineering (Basel, Switzerland)2021
Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates.
Article in Bioengineering (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Gelatin Hydrogel Crosslinking: From Molecular Design to Functional Soft Materials.Gels (Basel, Switzerland) · 2026Review
- Innovations in skeletal muscle regeneration: from physiology to bioengineering approaches for repair and restoration.Frontiers in physiology · 2026Review
- Visible-light-triggered BMP-2 release from enzymatically crosslinked marine collagen-alginate hydrogel blends enhances osteogenesis in dental pulp stem cells.Frontiers in physiology · 2026Article
- Construction of artificial organellesChemical science · 2025Review
- Combined stimuli of elasticity and microgrooves form aligned myotubes that characterize slow twitch muscles.Scientific reports · 2025Article
- Gelatin-Based Hydrogels for Peripheral Nerve Regeneration: A Multifunctional Vehicle for Cellular, Molecular, and Pharmacological Therapy.Gels (Basel, Switzerland) · 2025Review
- Decellularized Extracellular Matrix-Derived Hydrogels: a Powerful Class of Biomaterials for Skeletal Muscle Regenerative Engineering Applications.Regenerative engineering and translational medicine · 2025Article
- mTG-Gelatin phantoms as standardized testbeds for skin biomechanical measurements with Myoton.Journal of the mechanical behavior of biomedical materials · 2024Article
- 3D model of mouse embryonic pancreas and endocrine compartment using stem cell-derived mesoderm and pancreatic progenitors.iScience · 2024Article
- Mechanically Tough and Conductive Hydrogels Based on Gelatin and Z-Gln-Gly Generated by Microbial Transglutaminase.Polymers · 2024Article
- A Platform for Assessing Cellular Contractile Function Based on Magnetic Manipulation of Magnetoresponsive Hydrogel Films.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment.Asian journal of pharmaceutical sciences · 2023Article
- Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties.Stem cell research & therapy · 2023Review
- Design of highly active substrates using molecular docking for microbial transglutaminase detection.RSC advances · 2023Article
- Porous biomaterial scaffolds for skeletal muscle tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Fabrication of a Gelatin-Based Microdevice for Vascular Cell Culture.Micromachines · 2022Article
- Highly Organized Porous Gelatin-Based Scaffold by Microfluidic 3D-Foaming Technology and Dynamic Culture for Cartilage Tissue Engineering.International journal of molecular sciences · 2022Article
- Review
- Biobased Elastomer Nanofibers Guide Light-Controlled Human-iPSC-Derived Skeletal Myofibers.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Transglutaminase-Catalyzed Bottom-Up Synthesis of Polymer Hydrogel.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Engineered in vitro models of skeletal muscle are essential for efficiently screening drug safety and efficacy. However, conventional culture substrates poorly replicate physical features of native muscle and do not support long-term culture, which limits tissue maturity. Micromolded gelatin hydrogels cross-linked with microbial transglutaminase (gelatin-MTG hydrogels) have previously been shown to induce C21C2 myotube alignment and improve culture longevity. However, several properties of gelatin-MTG hydrogels have not been systematically characterized, such as changes in elastic modulus during incubation in culture-like conditions and their ability to support sarcomere maturation. In this study, various gelatin-MTG hydrogels were fabricated and incubated in ambient or culture-like conditions. Elastic modulus, mass, and transmittance were measured over a one- or two-week period. Compared to hydrogels in phosphate buffered saline (PBS) or ambient air, hydrogels in Dulbecco's Modified Eagle Medium (DMEM) and 5% CO
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