ArticleBrain sciences2021
BCI Training Effects on Chronic Stroke Correlate with Functional Reorganization in Motor-Related Regions: A Concurrent EEG and fMRI Study.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Biomarkers of stroke recovery using EEG-based resting-state functional connectivity: a systematic review.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Robot-Assisted Upper-Limb Rehabilitation After Stroke: A Systematic Review and Meta-Analysis of Cortical Reorganization and Neuroplasticity Biomarkers.Neural plasticity · 2026Pooled it
- Efficacy of brain-computer interface training with motor imagery-contingent feedback in improving upper limb function and neuroplasticity among persons with chronic stroke: a double-blinded, parallel-group, randomized controlled trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Neuromodulatory effects of voluntary-motor-effort-driven wrist-hand robot in sensorimotor dynamics after stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Advances in mechanisms of neuroplasticity induced by multimodal closed-loop brain-computer interfaces after stroke.Frontiers in human neuroscience · 2026Review
- Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026Review
- Understanding the Intersection Between Hormonal Dynamics and Brain Plasticity in Alzheimer's Disease: A Narrative Review for Implementing New Therapeutic Strategies.Health science reports · 2025Review
- Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.CNS & neurological disorders drug targets · 2025Review
- Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review.Fundamental research · 2025Review
- EEG-based sensorimotor neurofeedback for motor neurorehabilitation in children and adults: A scoping review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test: insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy.Neural regeneration research · 2024Article
- Several inaccurate or erroneous conceptions and misleading propaganda about brain-computer interfaces.Frontiers in human neuroscience · 2024Review
- Relationship between resting-state functional connectivity and change in motor function after motor imagery intervention in patients with stroke: a scoping review.Journal of neuroengineering and rehabilitation · 2023Article
- Review
- Recognition of single upper limb motor imagery tasks from EEG using multi-branch fusion convolutional neural network.Frontiers in neuroscience · 2023Article
- Brain-Computer Interfaces for Upper Limb Motor Recovery after Stroke: Current Status and Development Prospects (Review).Sovremennye tekhnologii v meditsine · 2023Review
- Applying antagonistic activation pattern to the single-trial classification of mental arithmetic.Heliyon · 2022Article
- Reconstructing Synergy-Based Hand Grasp Kinematics from Electroencephalographic Signals.Sensors (Basel, Switzerland) · 2022Article
- Dynamical Synergies of Multidigit Hand Prehension.Sensors (Basel, Switzerland) · 2022Article
- Resting State EEG Directed Functional Connectivity Unveils Changes in Motor Network Organization in Subacute Stroke Patients After Rehabilitation.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brain-computer interface (BCI)-guided robot-assisted training strategy has been increasingly applied to stroke rehabilitation, while few studies have investigated the neuroplasticity change and functional reorganization after intervention from multimodality neuroimaging perspective. The present study aims to investigate the hemodynamic and electrophysical changes induced by BCI training using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) respectively, as well as the relationship between the neurological changes and motor function improvement. Fourteen chronic stroke subjects received 20 sessions of BCI-guided robot hand training. Simultaneous EEG and fMRI data were acquired before and immediately after the intervention. Seed-based functional connectivity for resting-state fMRI data and effective connectivity analysis for EEG were processed to reveal the neuroplasticity changes and interaction between different brain regions. Moreover, the relationship among motor function improvement, hemodynamic changes, and electrophysical changes derived from the two neuroimaging modalities was also investigated. This work suggested that (a) significant motor function improvement could be obtained after BCI training therapy, (b) training effect significantly correlated with functional connectivity change between ipsilesional M1 (iM1) and contralesional Brodmann area 6 (including
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.