Evidence map›Paper›PMID 33418484›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2021

Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure.

Jacques A Bertrand, David F Woodward, Joseph M Sherwood, Alice Spenlehauer, Cristoforo Silvestri, Fabiana Piscitelli, Vincenzo Di Marzo, Maya Yamazaki, Kenji Sakimura, Yoko Inoue and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Jacques A BertrandDept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom.
David F WoodwardDept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom; JeniVision Inc., 5270, California Ave., Irvine, CA 92617, United States. Electronic address: david.woodward@imperial.ac.uk.
Joseph M SherwoodDept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom.
Alice SpenlehauerDept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom.
Cristoforo SilvestriDépartement de Médecine, Université Laval, 1050 Avenue de la Médecine, Québec, QC, Canada, G1V 0A6; Institut universitaire de cardiologie et de pneumologie de Québec, 2725 chemin Sainte-Foy, Québec, QC, Canada, G1V 4G5.
Fabiana PiscitelliInstitute of Biomolecular Chemistry, Via Campi Flegrei, 34 80078 Pozzuoli (NA), Italy.
Vincenzo Di MarzoDépartement de Médecine, Université Laval, 1050 Avenue de la Médecine, Québec, QC, Canada, G1V 0A6; Institut universitaire de cardiologie et de pneumologie de Québec, 2725 chemin Sainte-Foy, Québec, QC, Canada, G1V 4G5; Institute of Biomolecular Chemistry, Via Campi Flegrei, 34 80078 Pozzuoli (NA), Italy; Faculté des sciences de l'agriculture et de l'alimentation, Université Laval, 2425 Rue de l'Agriculture Bureau 1122, Québec, QC, Canada, G1V 0A6; Institut sur la Nutrition et les Aliments Fonctionnels, 440 Boulevard Hochelaga, Québec, QC, Canada, G1V 0A6.
Maya YamazakiDept. of Cellular Neurobiology (currently Dept. of Animal Model Development), Brain Research Institute, Niigata University, Niigata, 951-8585 Japan; Dept of Neurology, University of California at San Francisco, San Francisco, CA, United States.
Kenji SakimuraDept. of Cellular Neurobiology (currently Dept. of Animal Model Development), Brain Research Institute, Niigata University, Niigata, 951-8585 Japan.
Yoko InoueDept. of Cellular Neurobiology (currently Dept. of Animal Model Development), Brain Research Institute, Niigata University, Niigata, 951-8585 Japan.
Kikuko WatanabeFaculty of Nutrition, Kobe Gakuin University, Kobe, 651-2180, Japan.
Darryl R OverbyDept. of Bioengineering, Imperial College London, Prince Consort Road, South Kensington, London, SW7 2AZ, United Kingdom.
Imperial College London · GBNiigata University · JPInstitut Universitaire de Cardiologie et de Pneumologie de Québec · CAKobe Gakuin University · JPUniversité Laval · CA

Funding

eNOS-Dependent Mechanoregulation of Intraocular PressureR01EY022359 · NEI · DUKE UNIVERSITY · PI STAMER, W DANIEL · 2012 to 2025
$5.6M
NEI NIH HHS R01 EY022359
6 · The paper itself

Abstract

Prostamide/prostaglandin F synthase (PM/PGFS) is an enzyme with very narrow substrate specificity and is dedicated to the biosynthesis of prostamide F

Indexed as

Gene DeletionAnimalsChromatography, LiquidDinoprostDinoprostoneDisease Models, AnimalGene Knockout TechniquesHydroxyprostaglandin DehydrogenasesIntraocular PressureMaleMiceTandem Mass SpectrometryTonometry, OcularDinoprostDinoprostoneHydroxyprostaglandin Dehydrogenasesprostaglandin F2alpha ethanolamideFam213bIntraocular pressureProstaglandin F(2α)ProstaglandinsProstamide/prostaglandin F synthasePrxl2b, prostamide F2α

Identifiers

PMID33418484
PMCPMC9251352
OpenAlexW3118375212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.