Evidence map›Paper›PMID 33418322›Full record

ArticleThe Journal of surgical research2021

Leveraging Decision Curve Analysis to Improve Clinical Application of Surgical Risk Calculators.

Esmaeel Reza Dadashzadeh, Patrick Bou-Samra, Lauren V Huckaby, Giacomo Nebbia, Robert M Handzel, Patrick R Varley, Shandong Wu, Allan Tsung

Open access · greenAbstract read
In one paragraph

Article in The Journal of surgical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. CD45Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023
    Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Esmaeel Reza DadashzadehDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: dadashzadeher@upmc.edu.
Patrick Bou-SamraDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: patrick.bousamra@jhmi.edu.
Lauren V HuckabyDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Giacomo NebbiaDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biomedical Informatics, Intelligent Systems Program, University of Pittsburgh, Pittsburgh, Pennsylvania.
Robert M HandzelDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Patrick R VarleyDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Shandong WuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biomedical Informatics, Intelligent Systems Program, University of Pittsburgh, Pittsburgh, Pennsylvania.
Allan TsungDivision of Surgical Oncology, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio. Electronic address: allan.tsung@osumc.edu.
University of Pittsburgh Medical Center · USUniversity of Pittsburgh · USThe Ohio State University Wexner Medical Center · US

Funding

Vascular Surgery Research Training (VascTrain) ProgramT32HL098036 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Edith Tzeng · 2010 to 2026
$7.2M
NHLBI NIH HHS T32 HL098036
6 · The paper itself

Abstract

backgroundSurgical risk calculators (SRCs) have been developed for estimation of postoperative complications but do not directly inform decision-making. Decision curve analysis (DCA) is a method for evaluating prediction models, measuring their utility in guiding decisions. We aimed to analyze the utility of SRCs to guide both preoperative and postoperative management of patients undergoing hepatopancreaticobiliary surgery by using DCA.

methodsA single-institution, retrospective review of patients undergoing hepatopancreaticobiliary operations between 2015 and 2017 was performed. Estimation of postoperative complications was conducted using the American College of Surgeons SRC [ACS-SRC] and the Predictive OpTimal Trees in Emergency Surgery Risk (POTTER) calculator; risks were compared with observed outcomes. DCA was used to model optimal patient selection for risk prevention strategies and to compare the relative performance of the ACS-SRC and POTTER calculators.

resultsA total of 994 patients were included in the analysis. C-statistics for the ACS-SRC prediction of 12 postoperative complications ranged from 0.546 to 0.782. DCA revealed that an ACS-SRC-guided readmission prevention intervention, when compared with an all-or-none approach, yielded a superior net benefit for patients with estimated risk between 5% and 20%. Comparison of SRCs for venous thromboembolism intervention demonstrated superiority of the ACS-SRC for thresholds for intervention between 2% and 4% with the POTTER calculator performing superiorly between 4% and 8% estimated risk.

conclusionsSRCs can be used not only to predict complication risk but also to guide risk prevention strategies. This methodology should be incorporated into external validations of future risk calculators and can be applied for institution-specific quality improvement initiatives to improve patient outcomes.

Indexed as

Decision Support TechniquesAgedAged, 80 and overDigestive System Surgical ProceduresFemaleHumansMaleMiddle AgedPennsylvaniaPostoperative ComplicationsRetrospective StudiesRisk AssessmentDecision curve analysisNet benefitPostoperative complicationsRisk predictionSurgical risk calculators

Identifiers

PMID33418322
PMCPMC8991373
OpenAlexW3118949792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.