ArticleNeuroImage. Clinical2021
The sequence of structural, functional and cognitive changes in multiple sclerosis.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes.Nutrition & diabetes · 2025Trial
- Spatial gene expression and functional network abnormalities in multiple sclerosis: exploring biological influence on brain functional reorganization.Translational psychiatry · 2026Article
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- Do Transformers and CNNs Learn Different Concepts of Brain Age?Human brain mapping · 2025Article
- A data-driven model of disability progression in progressive multiple sclerosis.Brain communications · 2025Article
- Global functional connectivity reorganization reflects cognitive processing speed deficits and fatigue in multiple sclerosis.European journal of neurology · 2025Article
- Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex.Annals of clinical and translational neurology · 2025Article
- A 50-year data-driven model of disability and lesion load trajectories in progressive multiple sclerosis.Brain communications · 2025Article
- Understanding the Temporal Dynamics of Accelerated Brain Aging and Resilient Brain Aging: Insights from Discriminative Event-Based Analysis of UK Biobank Data.Bioengineering (Basel, Switzerland) · 2024Article
- Data-driven modelling of neurodegenerative disease progression: thinking outside the black box.Nature reviews. Neuroscience · 2024Review
- Early regional cerebral grey matter damage predicts long-term cognitive impairment phenotypes in multiple sclerosis: a 20-year study.Brain communications · 2024Article
- The sequence of regional structural disconnectivity due to multiple sclerosis lesions.Brain communications · 2023Article
- Patterns of brain atrophy in recently-diagnosed relapsing-remitting multiple sclerosis.PloS one · 2023Article
- Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis.Journal of neurology · 2022Article
- Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.Epilepsia · 2022Article
- Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis.BMC neurology · 2022Article
- A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia.Brain : a journal of neurology · 2022Article
- Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAs disease progression remains poorly understood in multiple sclerosis (MS), we aim to investigate the sequence in which different disease milestones occur using a novel data-driven approach.
methodsWe analysed a cohort of 295 relapse-onset MS patients and 96 healthy controls, and considered 28 features, capturing information on T2-lesion load, regional brain and spinal cord volumes, resting-state functional centrality ("hubness"), microstructural tissue integrity of major white matter (WM) tracts and performance on multiple cognitive tests. We used a discriminative event-based model to estimate the sequence of biomarker abnormality in MS progression in general, as well as specific models for worsening physical disability and cognitive impairment.
resultsWe demonstrated that grey matter (GM) atrophy of the cerebellum, thalamus, and changes in corticospinal tracts are early events in MS pathology, whereas other WM tracts as well as the cognitive domains of working memory, attention, and executive function are consistently late events. The models for disability and cognition show early functional changes of the default-mode network and earlier changes in spinal cord volume compared to the general MS population. Overall, GM atrophy seems crucial due to its early involvement in the disease course, whereas WM tract integrity appears to be affected relatively late despite the early onset of WM lesions.
conclusionData-driven modelling revealed the relative occurrence of both imaging and non-imaging events as MS progresses, providing insights into disease propagation mechanisms, and allowing fine-grained staging of patients for monitoring purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.