Evidence map›Paper›PMID 33418105›Full record

ReviewBiophysical chemistry2021

Recent trends in analytical and digital techniques for the detection of the SARS-Cov-2.

Chitrangada Das Mukhopadhyay, Pramita Sharma, Koel Sinha, Keshav Rajarshi

Open access · greenAbstract readReview
In one paragraph

Review in Biophysical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

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  13. Nucleic Acid Testing of SARS-CoV-2.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chitrangada Das MukhopadhyayCentre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology (IIEST), Shibpur, Howrah, West Bengal 711103, India. Electronic address: chitrangadam@chest.iiests.ac.in.
Pramita SharmaCentre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology (IIEST), Shibpur, Howrah, West Bengal 711103, India.
Koel SinhaCentre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology (IIEST), Shibpur, Howrah, West Bengal 711103, India.
Keshav RajarshiSchool of Community Science and Technology, Indian Institute of Engineering Science and Technology (IIEST), Shibpur, Howrah, West Bengal 711103, India.
Indian Institute of Engineering Science and Technology, Shibpur · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current global outbreak of COVID-19 due to SARS-CoV-2 is an unprecedented humanitarian crisis. Considering the gravity of its impact there is an immediate need to develop a detection technique that is sensitive, specific, fast, and affordable for the clinical diagnosis of the disease. Real time Polymerase Chain Reaction (RT-PCR)-based detection platforms are contemplated to be the gold standard to detect viral RNA. However, that may be susceptible to errors, and there is a risk of obtaining false results, which ultimately compromises the strategy of efficient disease management. Several modern techniques exhibiting assured results with enhanced sensitivity and specificity against the SARS-CoV-2 associated viral components or immune response against it have been developed and may be implemented. The review deals with the conventional RT-PCR detection techniques and compares them to other detection platforms viz., biosensor based detection of antigens, fluorescent or colorimetric detection systems including CRISPR-Cas 13 based SHERLOCK kit, CRISPR Cas-9 based FELUDA test kit, CRISPR DETECTR kit, Next Generation Sequencing or microarray-based kits. These modern techniques are great as a point of care detection methods but should be followed by RT PCR based detection for the confirmation of COVID-19 status.

Indexed as

Antigens, ViralBiosensing TechniquesClustered Regularly Interspaced Short Palindromic RepeatsCOVID-19High-Throughput Nucleotide SequencingHumansImmunoassayNucleic Acid Amplification TechniquesRNA, ViralSARS-CoV-2Antigens, ViralRNA, ViralBiosensorsCRISPR-CasImmunosensorMicroarrayNext-generation sequencingNucleic-acid amplificationRT-PCRSARS-CoV-2Serological test

Identifiers

PMID33418105
PMCPMC7768211
OpenAlexW3114938901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.