Evidence map›Paper›PMID 33418099›Full record

ReviewBone2021

Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review).

Fiona J Cook, Maighan Seagrove-Guffey, Steven Mumm, Deborah J Veis, William H McAlister, Vinieth N Bijanki, Deborah Wenkert, Michael P Whyte

Open access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Skeletal Fluorosis: A Case Report of Rare Diagnosis of Computer-cleaner Toxicosis.Clinical practice and cases in emergency medicine · 2025
    Article
  6. Review
  7. Skeletal fluorosis: an uncommon cause, yet a rescue treatment?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Skeletal Fluorosis: A Case of Inhalant Abuse Leading to a Diagnosis of Colon Cancer.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Fiona J CookDivision of Endocrinology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: cookf@ecu.edu.
Maighan Seagrove-GuffeyDivision of Endocrinology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: maighan.seagrove@unchealth.unc.edu.
Steven MummDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St Louis, MO 63110, USA; Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA. Electronic address: smumm@wustl.edu.
Deborah J VeisDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St Louis, MO 63110, USA; Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA. Electronic address: dveis@wustl.edu.
William H McAlisterMallinckrodt Institute of Radiology, Washington University School of Medicine at St. Louis Children's Hospital, St. Louis, MO 63110, USA. Electronic address: mcalisterw@mir.wustl.edu.
Vinieth N BijankiCenter for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA. Electronic address: vbijanki@shrinenet.org.
Deborah WenkertCenter for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Wenkert & Young, LLC, Thousand Oaks, CA, 91362, USA. Electronic address: wenkert@i1.net.
Michael P WhyteDivision of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St Louis, MO 63110, USA; Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA. Electronic address: mwhyte@shrinenet.org.
Barnes-Jewish Hospital · USEast Carolina University · USShriners Hospitals for Children - St. Louis · USSt. Louis Children's Hospital · US

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
NIAMS NIH HHS P30 AR074992
6 · The paper itself

Abstract

Skeletal fluorosis (SF) is endemic primarily in regions with fluoride (F)-contaminated well water, but can reflect other types of chronic F exposure. Calcium (Ca) and vitamin D (D) deficiency can exacerbate SF. A 51-year-old man with years of musculoskeletal pain and opiate use was hypocalcemic with secondary hyperparathyroidism upon manifesting recurrent long bone fractures. He smoked cigarettes, drank large amounts of cola beverage, and consumed little dietary Ca. Then, after 5 months of Ca and D

Indexed as

Bone DiseasesHyperparathyroidism, SecondaryOsteosclerosisBone DensityHumansMaleMiddle AgedParathyroid HormoneSpineParathyroid HormoneAtypical femoral fractureBone painBone scanDifluoroethaneDXAElevated bone massFluorideFluorocarbonFluorosisHip fractureHuffingHyperparathyroidismHypertrophic callusHypocalcemiaOsteolysisOsteomalaciaOsteoporosisOsteosclerosisPeriostitisTea consumption

Identifiers

PMID33418099
PMCPMC8142331
OpenAlexW3118675256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.