Evidence map›Paper›PMID 33418005›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Intravoxel incoherent motion (IVIM) modeling of diffusion MRI during chemoradiation predicts therapeutic response in IDH wildtype glioblastoma.

Pejman Jabehdar Maralani, Sten Myrehaug, Hatef Mehrabian, Aimee K M Chan, Max Wintermark, Chris Heyn, John Conklin, Benjamin M Ellingson, Saba Rahimi, Angus Z Lau and 12 more

Open access · bronzeAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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  4. Magnetic Resonance Imaging Sequences and Technologies in Adaptive Radiation Therapy.International journal of radiation oncology, biology, physics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Pejman Jabehdar MaralaniDepartment of Medical Imaging, Sunnybrook Health Sciences Center, University of Toronto, Canada. Electronic address: Pejman.Maralani@sunnybrook.ca.
Sten MyrehaugDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Hatef MehrabianDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Aimee K M ChanDepartment of Medical Imaging, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Max WintermarkDepartment of Radiology, Stanford University, United States.
Chris HeynDepartment of Medical Imaging, Sunnybrook Health Sciences Center, University of Toronto, Canada.
John ConklinDepartment of Radiology, Massachusetts General Hospital, United States.
Benjamin M EllingsonDepartment of Radiological Sciences and Psychiatry, University of California Los Angeles, United States.
Saba RahimiDepartment of Biomedical Engineering, University of Toronto, Canada.
Angus Z LauDepartment of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Canada.
Chia-Lin TsengDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Hany SolimanDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Jay DetskyDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Shadi DaghighiDepartment of Medical Imaging, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Julia KeithDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
David G MunozDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
Sunit DasDepartment of Surgery, Division of Neurosurgery, University of Toronto, Canada.
Eshetu G AtenafuDepartment of Biostatistics, University Health Network, Canada. Electronic address: e.atenafu@utoronto.ca.
Nir LipsmanDepartment of Surgery, Division of Neurosurgery, University of Toronto, Canada.
James PerryDepartment of Medicine, Division of Neurology, University of Toronto, Canada.
Greg StaniszDepartment of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, University of Toronto, Canada.
Sunnybrook Health Science Centre · CAUniversity of Toronto · CAMassachusetts General Hospital · USStanford University · USUniversity Health Network · CAUniversity of California, Los Angeles · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

backgroundPrediction of early progression in glioblastoma may provide an opportunity to personalize treatment. Simplified intravoxel incoherent motion (IVIM) MRI offers quantitative estimates of diffusion and perfusion metrics. We investigated whether these metrics, during chemoradiation, could predict treatment outcome.

methods38 patients with newly diagnosed IDH-wildtype glioblastoma undergoing 6-week/30-fraction chemoradiation had standardized post-operative MRIs at baseline (radiation planning), and at the 10th and 20th fractions. Non-overlapping T1-enhancing (T1C) and non-enhancing T2-FLAIR hyperintense regions were independently segmented. Apparent diffusion coefficient (ADC

resultsHigher ADC

conclusionADC

Indexed as

GlioblastomaChemoradiotherapyDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingMotionDiffusion MRIGlioblastomaIntravoxel incoherent motion imagingProgression-free SurvivalRadiotherapySurvival

Identifiers

PMID33418005
PMCPMC8186561
OpenAlexW3120412785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.