Evidence map›Paper›PMID 33417880›Full record

ArticleCurrent biology : CB2021

femaleless Controls Sex Determination and Dosage Compensation Pathways in Females of Anopheles Mosquitoes.

Elzbieta Krzywinska, Luca Ferretti, Jianwei Li, Jian-Chiuan Li, Chun-Hong Chen, Jaroslaw Krzywinski

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Mosquito sex determination: recent advances and applications.Current opinion in insect science · 2025
    Review
  7. Article
  8. Sex-specific transcriptome dynamics ofGenes & development · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elzbieta KrzywinskaThe Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
Luca FerrettiBig Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
Jianwei LiThe Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
Jian-Chiuan LiNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350401, Taiwan.
Chun-Hong ChenNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350401, Taiwan; National Mosquito-Borne Disease Control Research Center, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350401, Taiwan.
Jaroslaw KrzywinskiThe Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK. Electronic address: jaroslaw.krzywinski@pirbright.ac.uk.
The Pirbright Institute · GBNational Health Research Institutes · TWUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P019269/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007033Biotechnology and Biological Sciences Research Council BBS/E/I/00007038Biotechnology and Biological Sciences Research Council BBS/E/I/00007039
6 · The paper itself

Abstract

The insect sex determination and the intimately linked dosage compensation pathways represent a challenging evolutionary puzzle that has been solved only in Drosophila melanogaster. Analyses of orthologs of the Drosophila genes identified in non-drosophilid taxa

Indexed as

AnophelesDrosophila ProteinsMalariaAnimalsDNA-Binding ProteinsDosage Compensation, GeneticDrosophila melanogasterFemaleMaleMosquito VectorsNerve Tissue ProteinsSex Determination ProcessesTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsDSX protein, Drosophilafru protein, DrosophilaNerve Tissue ProteinsTranscription FactorsAnopheles gambiaefemale-specific lethalitygenetic vector controlmalaria vectorssex determination pathway evolutiontransgenesis

Identifiers

PMID33417880
PMCPMC7955153
OpenAlexW3118866058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.