ArticleJournal of hepato-biliary-pancreatic sciences2021
Sex differences in outcomes of acute pancreatitis: Findings from a nationwide analysis.
Article in Journal of hepato-biliary-pancreatic sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The IL-33/ST2 Signaling Axis Alleviates Splenic Injury in Severe Acute Pancreatitis by Inhibiting T-Cell Ferroptosis.Pancreas · 2026Article
- Pancreatitis-associated mortality in the United States: A population-based analysis of trends and disparities, 1999 to 2023.Medicine · 2026Article
- Alcoholic and non-alcoholic acute pancreatitis mortality in the United States, 2006-2023: A nationwide trend analysis.Scientific reports · 2026Article
- Global, Regional, and National Burden of Pancreatitis in Adults Aged 20-54 Years, 1990-2021: Insight from the Global Burden of Disease Study 2021.Digestive diseases and sciences · 2025Article
- Review
- Phospholipase D2: A biomarker implicated in various pancreatic diseases beyond acute pancreatitis.World journal of gastroenterology · 2025Article
- Reversal of global health inequality in pancreatitis burden from 1990 to 2021: A cross-national GBD 2021 analysis with forecast to 2030.Global health & medicine · 2025Article
- Article
- Global, regional, and national burdens of pancreatitis in children and adolescents aged 0-24 years from 1992 to 2021: a trend analysis based on the global burden of disease study 2021.Frontiers in public health · 2025Article
- Healthcare disparities in pancreatitis: knowledge gaps and next steps.Current opinion in gastroenterology · 2024Review
- Neutrophil-Creatinine Index: A New Prognostic Factor for Severity of Acute Pancreatitis.Medicina (Kaunas, Lithuania) · 2024Article
- Initiation time of double-filtration plasma apheresis affects the risk of persistent organ failure in hypertriglyceridaemia-induced acute pancreatitis: a retrospective study.Scientific reports · 2023Article
- [Sex-specific differences in gastroenterological diseases].Innere Medizin (Heidelberg, Germany) · 2023Review
- Obesity and alcoholic etiology as risk factors for multisystem organ failure in acute pancreatitis: Multinational study.United European gastroenterology journal · 2023Observational
- Impact of sex and comorbid diabetes on hospitalization outcomes in acute pancreatitis: A large United States population-based study.AIMS public health · 2023Article
- Age-period-cohort analysis of pancreatitis epidemiological trends from 1990 to 2019 and forecasts for 2044: a systematic analysis from the Global Burden of Disease Study 2019.Frontiers in public health · 2023Article
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10 authors.
Funding
Abstract
backgroundSex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database.
methodsThis was a retrospective study of adult patients with AP utilizing the 2016 and 2017 National Inpatient Sample via ICD-10 codes. The clinical courses of females were compared to that of males. The primary outcome was all-cause inpatient mortality. Secondary outcomes, including healthcare utilization, were assessed. Statistical analyses were performed using STATA, version 16.1.
resultsOf the 553 480 adult patients hospitalized with AP; 25.3% had AP secondary to alcohol (61.4% male, 38.6% female) and 17.44% secondary to gallstones (48.6% male, 51.4% female). Females were significantly older than males (52.81 years vs 50.97 years, P < .01). Females had a significantly lower likelihood of mortality (aOR: 0.69), shock (aOR: 0.64), sepsis (aOR: 0.70), acute kidney injury (aOR 0.66), intensive care unit admission (aOR 0.53), and pancreatic drainage (aOR 0.61) as compared to males (all with P < .01). There was no significant difference between females and males with regards to mean length of stay and hospitalization charges and costs.
conclusionsIn this large cohort of patients admitted for AP, despite being significantly older, we found that females had significantly improved clinical outcomes, including lower mortality, compared to males. Further prospective studies are needed to accurately understand these differences to guide clinical practice.
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