ArticlePloS one2021
Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 16 citations in OpenAlex.
- Establishing the distribution of cerebrovascular resistance using computational fluid dynamics and 4D flow MRI.Scientific reports · 2024Article
- Recruitment of pial collaterals and carotid occlusive disease in large-vessel occlusion ischemic stroke.Frontiers in neurology · 2024Article
- Ophthalmic artery reversal predicts contralateral body weakness symptoms better than carotid Doppler velocity-preliminary results.Annals of translational medicine · 2023Article
- Differential sensitivities to blood pressure variations in internal carotid and intracranial arteries: a numerical approach to stroke prediction.Scientific reports · 2023Article
- Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin.Scientific reports · 2022Article
- Determining Clinically-Viable Biomarkers for Ischaemic Stroke Through a Mechanistic and Machine Learning Approach.Annals of biomedical engineering · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
An internal carotid artery (ICA) stenosis can potentially decrease the perfusion pressure to the brain. In this study, computational fluid dynamics (CFD) was used to study if there was a hemispheric pressure laterality between the contra- and ipsilateral middle cerebral artery (MCA) in patients with a symptomatic ICA stenosis. We further investigated if this MCA pressure laterality (ΔPMCA) was related to the hemispheric flow laterality (ΔQ) in the anterior circulation, i.e., ICA, proximal MCA and the proximal anterior cerebral artery (ACA). Twenty-eight patients (73±6 years, range 59-80 years, 21 men) with symptomatic ICA stenosis were included. Flow rates were measured using 4D flow MRI data (PC-VIPR) and vessel geometries were obtained from computed tomography angiography. The ΔPMCA was calculated from CFD, where patient-specific flow rates were applied at all input- and output boundaries. The ΔPMCA between the contra- and ipsilateral side was 6.4±8.3 mmHg (p<0.001) (median 3.9 mmHg, range -1.3 to 31.9 mmHg). There was a linear correlation between the ΔPMCA and ΔQICA (r = 0.85, p<0.001) and ΔQACA (r = 0.71, p<0.001), respectively. The correlation to ΔQMCA was weaker (r = 0.47, p = 0.011). In conclusion, the MCA pressure laterality obtained with CFD, is a promising physiological biomarker that can grade the hemodynamic disturbance in patients with a symptomatic ICA stenosis.
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