Evidence map›Paper›PMID 33417471›Full record

ArticleCirculation. Arrhythmia and electrophysiology2021

Recording Intrinsic Nerve Activity at the Sinoatrial Node in Normal Dogs With High-Density Mapping.

Yufan Yang, Yuan Yuan, Johnson Wong, Michael C Fishbein, Peng-Sheng Chen, Thomas H Everett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yufan YangKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, IN (Y. Yang, Y. Yuan, J.W., P.-S.C., T.H.E.).
Yuan YuanKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, IN (Y. Yang, Y. Yuan, J.W., P.-S.C., T.H.E.).
Johnson WongKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, IN (Y. Yang, Y. Yuan, J.W., P.-S.C., T.H.E.).
Michael C FishbeinThe Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA (M.C.F.).
Peng-Sheng ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, IN (Y. Yang, Y. Yuan, J.W., P.-S.C., T.H.E.).
Thomas H EverettKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, IN (Y. Yang, Y. Yuan, J.W., P.-S.C., T.H.E.).

Funding

SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
High Resolution, Noninvasive Measurement and Functional Classification of Vagal Nerve Response Patterns in Relation to Gastroparesis Symptom Management using Gastric Electrical Stimulation TherapyOT2OD028183 · OD · PURDUE UNIVERSITY · PI CLEMENTS, ISAAC PERRY, EVERETT, THOMAS H · 2019 to 2021
$2.0M
Skin Sympathetic Nerve Activity and Cardiac ArrhythmiasR42DA043391 · NIDA · ARRHYTHMOTECH, LLC · PI EVERETT, THOMAS H · 2016 to 2017
$1.5M
Subcutaneous nerve stimulation for arrhythmia control.U18TR002208 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2017 to 2018
$1.4M
Neuromodulation for Atrial Fibrillation ControlR56HL071140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2016 to 2016
$461k
NCATS NIH HHS U18 TR002208NHLBI NIH HHS R01 HL139829NHLBI NIH HHS R56 HL071140NIDA NIH HHS R42 DA043391NIH HHS OT2 OD028183
6 · The paper itself

Abstract

backgroundIt is known that autonomic nerve activity controls the sinus rate. However, the coupling between local nerve activity and electrical activation at the sinoatrial node (SAN) remains unclear. We hypothesized that we would be able to record nerve activity at the SAN to investigate if right stellate ganglion (RSG) activation can increase the local intrinsic nerve activity, accelerate sinus rate, and change the earliest activation sites.

methodsHigh-density mapping of the epicardial surface of the right atrium including the SAN was performed in 6 dogs during stimulation of the RSG and after RSG stellectomy. A radio transmitter was implanted into 3 additional dogs to record RSG and local nerve activity at the SAN.

resultsHeart rate accelerated from 108±4 bpm at baseline to 125±7 bpm after RSG stimulation (

conclusionsLocal intrinsic nerve activity can be recorded at the SAN. Short bursts of these local nerve activities are present before each atrial activation during heart rate acceleration induced by stimulation of the RSG.

Indexed as

AnimalsBody Surface Potential MappingDogsFemaleHeart RateMaleModels, AnimalSinoatrial NodeStellate Ganglionaccelerationdogsheart ratesinoatrial nodestellate ganglion

Identifiers

PMID33417471
PMCPMC7887084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.