ArticleHuman brain mapping2021
White matter hyperintensities induce distal deficits in the connected fibers.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Damage to white matter networks resulting from small vessel disease and the effects on cognitive function.Scientific reports · 2025Article
- Sensitivity of diffusion tensor imaging to regional mixed cerebrovascular pathology.Brain communications · 2025Article
- White matter microstructural damage and its effect on cognitive impairment in patients with metabolic syndrome and cerebral small vessel disease.Frontiers in neurology · 2025Article
- Predictive value of cerebral perfusion and guanine nucleotide-binding protein, alpha-stimulating activity polypeptide in ischemic white matter lesions: a machine learning approach.Frontiers in neurology · 2025Article
- Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.Cognitive, affective & behavioral neuroscience · 2024Article
- The thalamic covariance network is associated with cognitive deficits in patients with cerebral small vascular disease.Annals of clinical and translational neurology · 2024Article
- Young versus older subject diffusion magnetic resonance imaging data for virtual white matter lesion tractography.Human brain mapping · 2023Article
- Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice.CNS neuroscience & therapeutics · 2023Article
- Spatial orientation - a stable marker for vascular cognitive impairment?Cerebral circulation - cognition and behavior · 2023Article
- Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin.Frontiers in neuroscience · 2023Article
- 3D finite-element brain modeling of lateral ventricular wall loading to rationalize periventricular white matter hyperintensity locations.Engineering with computers · 2022Article
- Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Brain and cognitive ageing: The present, and some predictions (…about the future).Aging brain · 2022Article
- FLAIR MRI biomarkers of the normal appearing brain matter are related to cognition.NeuroImage. Clinical · 2022Article
- White matter hyperintensities induce distal deficits in the connected fibers.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter hyperintensities (WMH) are common in elderly individuals and cause brain network deficits. However, it is still unclear how the global brain network is affected by the focal WMH. We aimed to investigate the diffusion of WMH-related deficits along the connecting white matters (WM). Brain magnetic resonance imaging data and neuropsychological evaluations of 174 participants (aged 74 ± 5 years) were collected and analyzed. For each participant, WMH lesions were segmented using a deep learning method, and 18 major WM tracts were reconstructed using automated quantitative tractography. The diffusion characteristics of distal WM tracts (with the WMH penumbra excluded) were calculated. Multivariable linear regression analysis was performed. We found that a high burden of tract-specific WMH was related to worse diffusion characteristics of distal WM tracts in a wide range of WM tracts, including the forceps major (FMA), forceps minor (FMI), anterior thalamic radiation (ATR), cingulum cingulate gyrus (CCG), corticospinal tract (CST), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus-parietal (SLFP), superior longitudinal fasciculus-temporal (SLFT), and uncinate fasciculus (UNC). Furthermore, a higher mean diffusivity (MD) of distal tracts was linked to worse attention and executive function in the FMI, right CCG, left ILF, SLFP, SLFT, and UNC. The effect of WMH on the microstructural integrity of WM tracts may propagate along tracts to distal regions beyond the penumbra and might eventually affect attention and executive function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.