Evidence map›Paper›PMID 33417276›Full record

ArticleMolecular systems biology2021

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.

Frode Norheim, Karthickeyan Chella Krishnan, Thomas Bjellaas, Laurent Vergnes, Calvin Pan, Brian W Parks, Yonghong Meng, Jennifer Lang, James A Ward, Karen Reue and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  5. Mechanisms Behind NAFLD: a System Genetics Perspective.Current atherosclerosis reports · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Frode NorheimDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Karthickeyan Chella KrishnanDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Thomas BjellaasVitas AS, Oslo, Norway.
Laurent VergnesDepartment of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA.
Calvin PanDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Brian W ParksDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Yonghong MengDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Jennifer LangDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
James A WardDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Karen ReueDepartment of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA.
Margarete MehrabianDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Thomas E GundersenVitas AS, Oslo, Norway.
Miklós PéterfyDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Knut T DalenDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Christian A DrevonDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Simon T HuiDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Aldons J LusisDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9013-0228
Marcus M SeldinDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-8026-4759
University of California, Los Angeles · USUniversity of Oslo · NOVitas (Norway) · NOUniversity of Wisconsin–Madison · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 1985 to 2019
$50.2M
NIDDK Network Coordinating UnitU24DK097771 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shuibing Chen, Jeffrey S. Grethe · 2013 to 2026
$20.9M
Sex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Gut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6M
A strategy for discovery of endocrine interactionsR00HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2020 to 2022
$745k
Investigating the sex-specific roles of PKLR and CHCHD6 in insulin resistance and NAFLDR00DK120875 · NIDDK · UNIVERSITY OF CINCINNATI · PI CHELLA KRISHNAN, KARTHICKEYAN · 2021 to 2023
$737k
Development of a strategy for endocrine axis discoveryK99HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SELDIN, MARCUS MICHAEL · 2018 to 2019
$268k
Investigating the sex-specific roles of PKLR and CHCHD6 in insulin resistance and NAFLDK99DK120875 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHELLA KRISHNAN, KARTHICKEYAN · 2020 to 2020
$92k
NHLBI NIH HHS K99 HL138193NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R00 HL138193NHLBI NIH HHS R01 HL144651NHLBI NIH HHS T32 HL069766NIDDK NIH HHS K99 DK120875NIDDK NIH HHS R00 DK120875NIDDK NIH HHS R01 DK117850NIDDK NIH HHS U24 DK097771NIDDK NIH HHS U54 DK120342
6 · The paper itself

Abstract

To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high-fat/high-sucrose diet for 8 weeks. Association mapping, correlation, structure analyses, and network modeling revealed pathways and genes underlying these interactions. In particular, our studies lead to the identification of Ifi203 and Map2k6 as regulators of hepatic phosphatidylcholine homeostasis and triacylglycerol accumulation, respectively. Our analyses highlight mechanisms for how genetic variation in hepatic lipidome can be linked to physiological and molecular phenotypes, such as microbiota composition.

Indexed as

AnimalsDiet, High-FatDisease Models, AnimalFatty LiverGene Expression ProfilingGene Expression RegulationGenetic VariationGlucoseInsulin ResistanceLipidomicsMaleMAP Kinase Kinase 6MiceNuclear ProteinsPhosphatidylcholinesTriglyceridesGlucoseIfi203 protein, mouseMap2k6 protein, mouseMAP Kinase Kinase 6Nuclear ProteinsPhosphatidylcholinesTriglyceridesgenome-wide association studieshepatic lipidomeHybrid Mouse Diversity Panelnon-alcoholic fatty liver diseasequantitative trait loci for lipids

Identifiers

PMID33417276
PMCPMC7792507
OpenAlexW3119374719

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.