Evidence map›Paper›PMID 33417219›Full record

ArticleMolecular neurobiology2021

Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats.

Fabrízio Dos Santos Cardoso, Júlio César Claudino Dos Santos, Francisco Gonzalez-Lima, Bruno Henrique Silva Araújo, Rodrigo Álvaro Brandão Lopes-Martins, Sérgio Gomes da Silva

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  16. Photobiomodulation for Neurodegenerative Diseases: A Scoping Review.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Fabrízio Dos Santos CardosoNúcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Av. Cândido Xavier de Almeida e Souza, 200, Mogi das Cruzes, SP, CEP 08780-911, Brazil.
Júlio César Claudino Dos SantosLaboratory of Neuroscience, Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, SP, Brazil.
Francisco Gonzalez-LimaDepartment of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA.
Bruno Henrique Silva AraújoBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil.
Rodrigo Álvaro Brandão Lopes-MartinsLaboratory of Biophotonics and Experimental Therapeutics, Institute of Research and Development, University of Vale do Paraíba (UNIVAP), São José dos Campos, SP, Brazil.
Sérgio Gomes da SilvaNúcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Av. Cândido Xavier de Almeida e Souza, 200, Mogi das Cruzes, SP, CEP 08780-911, Brazil. sgomesilva@hotmail.com.
Brazilian Center for Research in Energy and Materials · BRThe University of Texas at Austin · USUniversidade de Mogi das Cruzes · BRUniversidade do Vale do Paraíba · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. These novel metabolomics findings may help complement other laser-induced neurocognitive, neuroprotective, anti-inflammatory, and antioxidant effects described in the literature.

Indexed as

LasersLow-Level Light TherapyMetabolomeAgingAnimalsBrainEnergy MetabolismHomeostasisMaleMetabolomicsNeuronsOxidative StressRatsRats, WistarAgingBrainLaserMetabolic profileMetabolomicsPhotobiomodulation

Identifiers

PMID33417219
OpenAlexW3118607510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.