Evidence map›Paper›PMID 33417168›Full record

ArticleJournal of molecular neuroscience : MN2021

Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury.

Qiao Zheng, Jiawei Zhang, Xiaoshuang Zuo, Jiakai Sun, Zhuowen Liang, Xueyu Hu, Zhe Wang, Kun Li, Jiwei Song, Tan Ding and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

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  14. Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Qiao Zheng *Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Jiawei Zhang *Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xiaoshuang Zuo *Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Jiakai SunDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Zhuowen LiangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xueyu HuDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. huxueyu@fmmu.edu.cn.
Zhe WangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. wangzhe@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-7573-1583
Kun LiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Jiwei SongDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Tan DingDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xuefeng ShenDepartment of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Yangguang MaDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Penghui LiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xijing Hospital · CNAir Force Medical University · CN

Funding

Key Science and Technology Program in Social Development of Shaanxi Province 2017SF-021Key Science and Technology Program in Social Development of Shaanxi Province 2020ZDLSF02-05National Key Scientific Instrument and Equipment Development Projects of China (CN) 81070996National Natural Scientific Foundation of China Grant 81101352
6 · The paper itself

Abstract

To study the effect of photobiomodulation (PBM) on axon regeneration and secretion change of dorsal root ganglion (DRG) under oxidative stress after spinal cord injury (SCI), and further explore the effect of changes in DRG secretion caused by PBM on the polarization of macrophages. The PBM-DRG model was constructed to perform PBM on neurons under oxidative stress simulated in vitro. And the irradiation conditions were as follows: wavelength, 810 nm; power density, 2 mW/cm

Indexed as

Oxidative StressSpinal Cord RegenerationAnimalsAxonsCell DifferentiationCells, CulturedChemokine CCL2FemaleGanglia, SpinalInterleukin-1betaLightMacrophagesMaleMiceMice, Inbred BALB CPhototherapyCcl2 protein, mouseChemokine CCL2Interleukin-1betaTumor Necrosis Factor-alphaAxon regenerationCCL2Dorsal root ganglionMacrophage polarizationPhotobiomodulationSpinal cord injury

Identifiers

PMID33417168
OpenAlexW3120895352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.