Evidence map›Paper›PMID 33417000›Full record

ArticleJournal of neurology2021

Longitudinal cognitive and functional changes in primary progressive aphasia.

David Foxe, Muireann Irish, Anne Hu, James Carrick, John R Hodges, Rebekah M Ahmed, James R Burrell, Olivier Piguet

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06181500 (Home-Based Exercise in Primary Progressive Aphasia), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06181500 nacompletednot on this mapstarted 2023, after this paper: background citation

Home-Based Exercise in Primary Progressive Aphasia: A Pilot Study

TypeinterventionalSponsorMontreal Heart InstituteRan2023 to 2024Enrolled13ConditionsPrimary Progressive Aphasia, Neurodegenerative Diseases, Logopenic Progressive Aphasia, Semantic DementiaArmsHome-based multicomponent exercise intervention program
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Pooled it
  2. Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

David FoxeSchool of Psychology, The University of Sydney, Sydney, Australia.
Muireann IrishSchool of Psychology, The University of Sydney, Sydney, Australia.
Anne HuBrain and Mind Centre, The University of Sydney, 94 Mallett St, Sydney, NSW, 2006, Australia.
James CarrickSchool of Psychology, The University of Sydney, Sydney, Australia.
John R HodgesBrain and Mind Centre, The University of Sydney, 94 Mallett St, Sydney, NSW, 2006, Australia.
Rebekah M AhmedBrain and Mind Centre, The University of Sydney, 94 Mallett St, Sydney, NSW, 2006, Australia.
James R BurrellBrain and Mind Centre, The University of Sydney, 94 Mallett St, Sydney, NSW, 2006, Australia.
Olivier PiguetSchool of Psychology, The University of Sydney, Sydney, Australia. olivier.piguet@sydney.edu.au.ORCID http://orcid.org/0000-0002-6696-1440
The University of Sydney · AUUniversity of Technology Sydney · AU

Funding

Australian Research Council Future Fellowship FT160100096Centre of Excellence in Cognition and its Disorders, Australian Research Council CE11000102National Health and Medical Research Council GNT1037746National Health and Medical Research Council GNT1072451National Health and Medical Research Council GNT1103258
6 · The paper itself

Abstract

objectiveThe variants of primary progressive aphasia (PPA) are predominantly diagnosed on the basis of specific profiles of language impairments. Deficits in other cognitive domains and their evolution over time are less well documented. This study examined the cognitive profiles of the PPA variants over time and determined the contribution of cognition on functional capacity.

methodsLongitudinal performance on the Addenbrooke's Cognitive Examination-III (ACE-III) total and cognitive subdomains were investigated in 147 PPA individuals (41 logopenic [lv-PPA], 44 non-fluent [nfv-PPA], and 62 semantic variants [sv-PPA]). The relative contribution of ACE-III subdomain scores to overall functional capacity over time was identified using mixed and hierarchical regression modelling.

resultsThe annual rate of global ACE-III decline was twice that in lv-PPA than in nfv-PPA and sv-PPA, despite lv-PPA performing intermediate to the other variants at baseline assessment. Notably, attention and visuospatial subdomains declined faster in lv-PPA than in nfv-PPA and sv-PPA; and memory impairment was more severe in lv-PPA than in nfv-PPA at all time points. Functional decline was comparable across PPA variants; however, the contribution of cognition on functional capacity varied across variants and over time.

conclusionThe cognitive profiles of the PPA variants are distinct at baseline and over time. Crucially, cognitive decline in lv-PPA was more widespread and pervasive than in nfv-PPA and sv-PPA. Our findings also demonstrate the complex interplay between cognition and functional capacity. This study underscores the importance of routinely assessing cognition and functional capacity in PPA to improve diagnostic accuracy and provide targeted support services.

Indexed as

Aphasia, Primary ProgressiveCognitive DysfunctionCognitionHumansLanguageMemory DisordersAddenbrooke’s Cognitive ExaminationCognitive assessmentDementia stagingFunctional capacityLongitudinal assessment

Identifiers

PMID33417000
OpenAlexW3119076344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.