Evidence map›Paper›PMID 33416956›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Left ventricular regional glucose metabolism in combination with septal scar extent identifies CRT responders.

Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Jan Bogaert, Johan Nuyts, Gabor Vöros, Rik Willems, Camilla Kjellstad Larsen, John M Aalen, Jan Gunnar Fjeld and 5 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Ganna DegtiarovaNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8525-0938
Piet ClausCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. piet.claus@kuleuven.be.
Jürgen DuchenneCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Jan BogaertDepartment of Radiology, University Hospitals Leuven, Leuven, Belgium.
Johan NuytsNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Gabor VörosCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Rik WillemsCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Camilla Kjellstad LarsenDepartment of Cardiology, Oslo University Hospital, Oslo, Norway.
John M AalenDepartment of Cardiology, Oslo University Hospital, Oslo, Norway.
Jan Gunnar FjeldDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Caroline StokkeDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Einar HoppDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Otto Armin SmisethDepartment of Cardiology, Oslo University Hospital, Oslo, Norway.
Jens-Uwe VoigtCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Olivier GheysensNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
KU Leuven · BEOslo University Hospital · NOCliniques Universitaires Saint-Luc · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac resynchronization therapy (CRT) is effective in selective heart failure (HF) patients, but non-response rate remains high. Positron emission tomography (PET) may provide a better insight into the pathophysiology of left ventricular (LV) remodeling; however, its role for evaluating and selecting patients for CRT remains uncertain. PURPOSE: We investigated if regional LV glucose metabolism in combination with myocardial scar could predict response to CRT.

methodsConsecutive CRT-eligible HF patients underwent echocardiography, cardiac magnetic resonance (CMR), and

resultsWe evaluated 88 patients (67 ± 10 years, 72% males).

conclusionsFDG SLR can be used as a predictor of CRT response and combined with septal scar extent, CRT responders can be distinguished from non-responders with high diagnostic accuracy. Further studies are needed to verify whether this imaging approach can prospectively be used to optimize patient selection.

Indexed as

Cardiac Resynchronization TherapyHeart FailureCicatrixContrast MediaFemaleGadoliniumGlucoseHumansMaleTomography, X-Ray ComputedTreatment OutcomeVentricular RemodelingContrast MediaGadoliniumGlucose18F-fluorodeoxyglucoseCardiac magnetic resonanceCardiac resynchronization therapyDyssynchronyPositron emission tomographyScar

Identifiers

PMID33416956
OpenAlexW3120107785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.