Evidence map›Paper›PMID 33416921›Full record

ArticlePediatric cardiology2021

Antiarrhythmic Treatment Duration and Tachycardia Recurrence in Infants with Supraventricular Tachycardia.

Othman A Aljohani, Nicole L Herrick, Alejandro A Borquez, Suzanne Shepard, Matthew E Wieler, James C Perry, Matthew R Williams

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Review
  2. Article
  3. Article
  4. Observational
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Othman A AljohaniDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA. Dr.othman.aljohani@gmail.com.ORCID http://orcid.org/0000-0002-8195-3799
Nicole L HerrickDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA.
Alejandro A BorquezDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA.
Suzanne ShepardDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA.
Matthew E WielerDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA.
James C PerryDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA.
Matthew R WilliamsDivision of Pediatric Cardiology, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, USA.
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We sought to assess the effect of a shorter medication treatment course (up to 4-6 months of age) on the recurrence of infantile supraventricular tachycardia (SVT). This was a retrospective review of infants with SVT diagnosed at age 0-12 months at Rady Children's Hospital (2010-2017). Infants with structural congenital heart disease, automatic tachycardias, atrial flutter, or lack of follow-up data were excluded. Seventy-four infants met criteria. Median age at diagnosis was 6 days (IQR 0-21 days); 28.4% presented with fetal tachycardia. Median gestational age was 38.4 weeks (IQR 36-40), 30% were preterm. Median age at medication discontinuation was 6.7 months (IQR 4.6-9.8). Therapy was stopped at younger age in patients managed by pediatric electrophysiologist (vs. general pediatric cardiologist): 4.9 vs. 8.6 months (p = 0.03). Thirty-eight patients (51.4%) were treated for < 6 months; 32.4% for 6-12 months, and 16.2% for > 12 months. SVT recurrence was similar for these groups: 13.2% vs. 16.7%, and 33.3%, respectively, (p = 0.27). Most patients with recurrence required emergency care, though none had significant adverse outcomes. Infants with SVT and structurally normal cardiac anatomy, who remain recurrence free on a single agent, have no increased risk of recurrence with shorter treatment courses of 4-6 months, compared to traditional treatment duration of 6-12 months.

Indexed as

Anti-Arrhythmia AgentsChildChild, PreschoolDuration of TherapyFemaleHumansInfantInfant, NewbornMaleRecurrenceRetrospective StudiesTachycardia, SupraventricularAnti-Arrhythmia AgentsAntiarrhythmicInfantsSupraventricular tachycardiaSVT

Identifiers

PMID33416921
OpenAlexW3120114864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.