ArticleEndocrine connections2021
Clinical data and basal gonadotropins in the diagnosis of central precocious puberty in girls.
Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Meta-analysis of machine learning models for the diagnosis of central precocious puberty based on clinical, hormonal (laboratory) and imaging data.Frontiers in endocrinology · 2024Pooled it
- Adrenal Androgens, Estrone, and Insulin-Like Growth Factor 1 Are Associated with Thelarche without Gonadotropin Activation in Girls.Hormone research in paediatrics · 2026Article
- Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index.Journal of endocrinological investigation · 2026Article
- Diagnostic utility of basal luteinizing hormone in evaluating central precocious puberty.Journal of the Endocrine Society · 2026Article
- Interpretable XGBoost model identifies idiopathic central precocious puberty in girls using four clinical and imaging features.BMC endocrine disorders · 2025Article
- [Construction of a diagnostic model and scoring system for central precocious puberty in girls, with external validation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Does Basal Morning Luteinizing Hormone (bLH) Predict Central Precocious Puberty (CPP) in Girls?Medicina (Kaunas, Lithuania) · 2024Article
- Changes in blood glucose and lipid metabolism levels in children with central precocious puberty and its correlation with obesity.Frontiers in pediatrics · 2024Article
- Basal gonadotropin levels combine with pelvic ultrasound and pituitary volume: a machine learning diagnostic model of idiopathic central precocious puberty.BMC pediatrics · 2023Article
- Differential diagnosis of precocious puberty in girls during the COVID-19 pandemic: a pilot study.BMC pediatrics · 2023Article
- Leuprolide and triptorelin treatment in children with idiopathic central precocious puberty: an efficacy/tolerability comparison study.Frontiers in pediatrics · 2023Article
- Clinical significance of serum MBD3 detection in girls with central precocious puberty.Open medicine (Warsaw, Poland) · 2023Article
- Impact of 6-month triptorelin formulation on predicted adult height and basal gonadotropin levels in patients with central precocious puberty.Frontiers in endocrinology · 2023Article
- Vitamin D status and parathyroid hormone assessment in girls with central precocious puberty.Journal of endocrinological investigation · 2022Article
- Diagnostic Value of LH Peak Value of the GnRH Stimulation Test for Girls with Precocious Puberty and Its Correlation with Body Mass Index.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to analyze whether some auxological characteristics or a single basal gonadotropin measurement will be sufficient to distinguish the prepubertal from pubertal status.
methodsAuxologycal characteristics were recorded and serum LH and FSH were measured by immunochemiluminescence assays before and after GnRH stimulation test in a sample of 241 Caucasian girls with breast budding between 6- and 8-years old. Peak LH levels higher than 5 IU/L were considered a pubertal response. Area under the curve, cut-off points, sensitivity, and specificity for auxologycal variables and basal gonadotropins levels were determined by receiver operating curves.
resultsThere were no significant differences in age at onset, weight, height, BMI and height velocity between both groups. Bone age was significantly higher in pubertal girls (P < 0.05), although with limited discriminatory capacity. The sensitivity and specificity for the basal LH levels were 89 and 82%, respectively, for a cut off point of 0.1 IU/L. All girls in the pubertal group had a basal LH higher than 1.0 IU/L (positive predictive value of 100%). There was a wide overlap of basal FSH and LH/FSH ratio between prepubertal and pubertal girls.
conclusionsAuxologycal characteristics should not be used only in the differential diagnosis between prepubertal from pubertal status in 6- to 8-year-old girls. We found a high specificity of a single basal LH sample and it would be useful for establishing the diagnosis of puberty in this age group, reducing the need for GnRH stimulation testing.
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