Evidence map›Paper›PMID 33416512›Full record

ArticleEndocrine connections2021

Higher blood pressure in normal weight women with PCOS compared to controls.

Jan Roar Mellembakken, Azita Mahmoudan, Lars Mørkrid, Inger Sundström-Poromaa, Laure Morin-Papunen, Juha S Tapanainen, Terhi T Piltonen, Angelica Lindén Hirschberg, Elisabet Stener-Victorin, Eszter Vanky and 4 more

Open access · goldAbstract read
In one paragraph

Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  20. Testosterone: Vital to female physiology.Women's health (London, England)
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Jan Roar MellembakkenDivision of Gynecology and Obstetrics, Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-6684-9048
Azita MahmoudanDivision of Gynecology and Obstetrics, Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway.
Lars MørkridDepartment of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Inger Sundström-PoromaaDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Laure Morin-PapunenDepartment of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland.
Juha S TapanainenDepartment of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland.
Terhi T PiltonenDepartment of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland.ORCID 0000-0002-9921-7300
Angelica Lindén HirschbergDepartment of Women's and Children's Health, Karolinska Institutet and Department of Gynecology and Reproductive Medicine, Stockholm, Sweden.ORCID 0000-0001-6481-6277
Elisabet Stener-VictorinDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Eszter VankyDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, UK.
Pernille RavnDepartment of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Richard Christian JensenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Marianne Skovsager AndersenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Dorte GlintborgDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-8338-8025
Odense University Hospital · DKOslo University Hospital · NOKarolinska Institutet · SEOulu University Hospital · FISt Olav's University Hospital · NOUniversity of Helsinki · FIUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI.

methodsFrom a Nordic cross-sectional base of 2615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI < 25 kg/m2 (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurement of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles).

resultsThe median age for women with PCOS were 28 (25, 32) years and median BMI was 22.2 (20.7, 23.4) kg/m2. Systolic BP was 118 (109, 128) mmHg in women with PCOS compared to 110 (105, 120) mmHg in controls and diastolic BP was 74 (67, 81) vs 70 (64, 75) mmHg, both P < 0.001. The prevalence of women with BP ≥ 140/90 mmHg was 11.1% (57/512) in women with PCOS vs 1.8% (5/281) in controls, P < 0.001. In women ≥ 35 years the prevalence of BP ≥ 140/90 mmHg was comparable in women with PCOS and controls (12.7% vs 9.8%, P = 0.6). Using multiple regression analyses, the strongest association with BP was found for age, waist circumference, and total cholesterol in women with PCOS.

conclusionsNormal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.

Indexed as

blood pressurehypertensionpolycystic ovary syndrome

Identifiers

PMID33416512
PMCPMC7983477
OpenAlexW3118987787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.