Evidence map›Paper›PMID 33416499›Full record

ArticleeLife2021

A Bayesian analysis of the association between

Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E Thwaites, Mark Troll and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Gaucher disease protects against tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
  12. Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Tuberculosis of the Spinal Cord.Annals of Indian Academy of Neurology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 6 countries.

Laura WhitworthMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID 0000-0002-8232-4601
Jacob CoxonTrinity College, Cambridge, United Kingdom.
Arjan van LaarhovenDepartment of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-6607-4075
Nguyen Thuy Thuong ThuongOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Sofiati DianUniversitas Padjadjaran, TB-HIV Research Center, Faculty of Medicine, Bandung, Indonesia.
Bachti AlisjahbanaUniversitas Padjadjaran, TB-HIV Research Center, Faculty of Medicine, Bandung, Indonesia.
Ahmad Rizal GaniemUniversitas Padjadjaran, TB-HIV Research Center, Faculty of Medicine, Bandung, Indonesia.
Reinout van CrevelDepartment of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, Netherlands.
Guy E ThwaitesOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.ORCID 0000-0002-2858-2087
Mark TrollMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Paul H EdelsteinMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID 0000-0002-4069-5279
Roger SewellTrinity College, Cambridge, United Kingdom.ORCID 0000-0003-4267-7055
Lalita RamakrishnanMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID 0000-0003-0692-5533
MRC Laboratory of Molecular Biology · GBDr. Hasan Sadikin General Hospital · IDRadboud University Nijmegen · NLTrinity College London · GBPadjadjaran University · IDUniversity of Oxford · GBUniversity of the Witwatersrand · ZA

Funding

ULTIMATER01AI145781 · NIAID · STICHTING RADBOUD UNIVERSITEIT · PI THWAITES, GUY, VAN CREVEL, REINOUT · 2019 to 2023
$4.4M
Host-Responses to Mycobacterium Infection in ZebrafishR37AI054503 · NIAID · UNIVERSITY OF WASHINGTON · PI RAMAKRISHNAN, LALITA · 2012 to 2021
$3.1M
NIAID NIH HHS R01 AI145781NIAID NIH HHS R37 AI054503Wellcome Trust 103950/Z/14Wellcome Trust 110179/Z/15/Z
6 · The paper itself

Abstract

Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset of deaths. In Vietnam, the survival benefit of anti-inflammatory corticosteroids was most pronounced in patients with a C/T promoter variant in the leukotriene A

Indexed as

GenotypeLongevityAdultAgedAged, 80 and overBayes TheoremEpoxide HydrolasesHumansMiddle AgedTuberculosis, MeningealYoung AdultEpoxide Hydrolasesleukotriene A4 hydrolaseBayesian inferencedexamethasonegeneticsgenomicshumaninfectious diseaseleukotriene A4 hydrolasemicrobiologypharmacogenomicsTB meningitis

Identifiers

PMID33416499
PMCPMC7793626
OpenAlexW3120635211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.