Evidence map›Paper›PMID 33416459›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes.

Leonid Tyan, Daniel Turner, Karlie R Komp, Roman Y Medvedev, Evi Lim, Alexey V Glukhov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Angiotensin receptors and αPflugers Archiv : European journal of physiology · 2024
    Article
  4. Caveolae-associated cAMP/CaJournal of molecular and cellular cardiology · 2023
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Leonid TyanDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0001-9734-7286
Daniel TurnerDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0001-8159-2594
Karlie R KompDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Roman Y MedvedevDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0003-1174-2993
Evi LimDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Alexey V GlukhovDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0003-2076-9688
University of Wisconsin–Madison · US

Funding

Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
NHLBI NIH HHS R01 HL141214NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Angiotensin II (AngII) is a key mediator of the renin-angiotensin system and plays an important role in the regulation of cardiac electrophysiology by affecting various cardiac ion currents, including transient outward potassium current,

Indexed as

Angiotensin IIAnimalsCaveolin 3FemaleHeart AtriaMaleMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacPotassiumProtein Kinase CReceptor, Angiotensin, Type 1Shal Potassium ChannelsAngiotensin IICav3 protein, mouseCaveolin 3Kcnd2 protein, mouseKcnd3 protein, mousePotassiumProtein Kinase CReceptor, Angiotensin, Type 1Shal Potassium Channelsangiotensin IIangiotensin II receptor 1atrial cardiomyocytecaveolin 3transient outward potassium current (Ito)

Identifiers

PMID33416459
PMCPMC8082791
OpenAlexW3119159936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.