ReviewAmerican journal of physiology. Heart and circulatory physiology2021
Sympathetic transduction in humans: recent advances and methodological considerations.
Review in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Binge Alcohol Consumption Elevates Sympathetic Transduction to Blood Pressure: A Randomized Controlled Trial.Hypertension (Dallas, Tex. : 1979) · 2024Trial
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Article
- Spontaneous indices correlate with baroreflex gain only in adults with spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Changes in cardio-respiratory-vascular coupling dynamics across altitude gradients: a shift from linear synchrony to nonlinear complexity.Frontiers in physiology · 2026Article
- Resting beat-to-beat blood pressure variability is preserved in young adults with major depressive disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Dissecting the exercise pressor reflex in heart failure: A multi-step failure.Autonomic neuroscience : basic & clinical · 2025Review
- The impact of androgens on cardiovascular control mechanisms in polycystic ovary syndrome: Recent advances and translational approaches.The Journal of physiology · 2025Review
- Differential effects of female aging on sympathetic blood pressure regulation at rest and during stress in humans.Physiological reports · 2025Article
- Alternate quantification approaches for cold-induced vasodilation in human glabrous skin.Frontiers in physiology · 2025Article
- Impaired Neurocirculatory Control in Chronic Kidney Disease: New Evidence for Blunted Sympathetic Baroreflex and Reduced Sympathetic Transduction.Function (Oxford, England) · 2024Article
- Respiratory modulation of sympathetic transduction to blood pressure in health and type 2 diabetes.The Journal of physiology · 2024Article
- Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Hyperaemia during dynamic handgrip exercise is preserved in healthy young subjects after recovery from COVID-19.Experimental physiology · 2024Article
- Sympathetic vascular transduction and baroreflex sensitivity in the context of severe COPD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ever since their origin more than one half-century ago, microneurographic recordings of sympathetic nerve activity have significantly advanced our understanding of the generation and regulation of central sympathetic outflow in human health and disease. For example, it is now appreciated that a myriad of disease states exhibit chronic sympathetic overactivity, a significant predictor of cardiovascular morbidity and mortality. Although microneurographic recordings allow for the direct quantification of sympathetic outflow, they alone do not provide information with respect to the ensuing sympathetically mediated vasoconstriction and blood pressure (BP) response. Therefore, the study of vascular and/or BP responses to sympathetic outflow (i.e., sympathetic transduction) has now emerged as an area of growing interest within the field of neural cardiovascular control in human health and disease. To date, studies have primarily examined sympathetic transduction under two distinct paradigms: when reflexively evoking sympatho-excitation through the induction of a laboratory stressor (i.e., sympathetic transduction during stress) and/or following spontaneous bursts of sympathetic outflow occurring under resting conditions (i.e., sympathetic transduction at rest). The purpose of this brief review is to highlight how our physiological understanding of sympathetic transduction has been advanced by these studies and to evaluate the primary analytical techniques developed to study sympathetic transduction in humans. We also discuss the framework by which the assessment of sympathetic transduction during stress reflects a fundamentally different process relative to sympathetic transduction at rest and why findings from investigations using these different techniques should be interpreted as such and not necessarily be considered one and the same.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.