Evidence map›Paper›PMID 33416105›Full record

ArticleInternational journal of molecular medicine2021

Downregulation of hsa_circ_0026123 suppresses ovarian cancer cell metastasis and proliferation through the miR‑124‑3p/EZH2 signaling pathway.

Xiaoyun Yang, Jianjun Wang, Huaifang Li, Yi Sun, Xiaowen Tong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xiaoyun YangDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China.
Jianjun WangDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China.
Huaifang LiDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China.
Yi SunDepartment of Gynecology and Obstetrics, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200336, P.R. China.
Xiaowen TongDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China.
Tongji University · CNTongji Hospital · CNTongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) play a role in various types of cancer. The present study suggested that hsa_circ_0026123 expression was upregulated in ovarian cancer (OVA), which was associated with its role in OVA. However, the role of hsa_circ_0026123 in OVA cell invasion and proliferation remains unclear. In the present study, OVA tissues and cell lines were used to investigate the functions of hsa_circ_0026123. The associations between hsa_circ_0026123, miR‑124‑3p and enhancer of zeste homolog 2 (EZH2) were examined using a luciferase reporter assay. RT‑qPCR and western blot analysis were used for gene and protein expression analysis, respectively. Tumor growth was detected using nude mouse tumor xenografts derived from SKOV3 cells, with or without hsa_circ_0026123 downregulation. The results confirmed that hsa_circ_0026123 expression was upregulated in OVA tissues and cell lines, while hsa_circ_0026123 silencing suppressed cell proliferation and migration; it also suppressed the expression of cancer stem cell (CSC) differentiation‑related markers in either in vivo or in vitro experiments. The data revealed that hsa_circ_0026123 downregulation suppressed EZH2 expression by miR‑124‑3p 'sponging', which was confirmed by rescue experiments and luciferase reporter assays. The results revealed that hsa_circ_0026123 silencing suppressed ovarian cancer cell progression via the miR‑124‑3p/EZH2 signaling pathway. Overall, the findings demonstrated that hsa_circ_0026123 knockdown inhibited OVA cell progression by regulating the miR‑124‑3p/EZH2 axis. This methodology may thus be used for the targeted therapy of OVA, as well as a candidate biomarker for the diagnosis and treatment of OVA.

Indexed as

Down-RegulationGene Expression Regulation, NeoplasticSignal TransductionAgedAnimalsCell Line, TumorCell ProliferationEnhancer of Zeste Homolog 2 ProteinFemaleHumansMiceMice, Inbred BALB CMice, NudeMicroRNAsMiddle AgedNeoplasm MetastasisEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMicroRNAsMIRN124 microRNA, humanNeoplasm ProteinsRNA, CircularRNA, Neoplasmcancer stem cell markersenhancer of zeste homolog 2hsa_circ_0026123miR-124-3povarian cancer

Identifiers

PMID33416105
PMCPMC7797451
OpenAlexW3109620875

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.