ArticlePlant biotechnology journal2021
BED domain-containing NLR from wild barley confers resistance to leaf rust.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Genome-wide exploration of bacterial leaf blight resistance and fine mapping of major resistance gene (Bb13) in upland cotton (Gossypium hirsutum L.).The plant genome · 2026Article
- Genome-wide identification and characterization of theFrontiers in plant science · 2026Article
- The pan-NLRome and diversity of Watkins wheat provide genetic resources for improving disease resistance and adaptation.Plant communications · 2025Article
- Investigating the Role and Response of Root Groups ofPlant-environment interactions (Hoboken, N.J.) · 2025Article
- Predictions of Genes Conferring Resistance toPlants (Basel, Switzerland) · 2025Article
- Foliar disease resistance phenomics of fungal pathogens: image-based approaches for mapping quantitative resistance in cereal germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Divergent molecular pathways govern temperature-dependent wheat stem rust resistance genes.Nature communications · 2025Article
- An optimized disease resistance gene cloning workflow for wheat.Nature communications · 2025Article
- Genetic and physical localization of a leaf rust susceptibility gene in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Essential role of rice ERF101 in the perception of TAL effectors and immune activation mediated by the CC-BED NLR Xa1.Plant cell reports · 2025Article
- An Aegilops longissima NLR protein with integrated CC-BED module mediates resistance to wheat powdery mildew.Nature communications · 2024Article
- The wheat stripe rust resistance gene YrNAM is Yr10.Nature communications · 2024Article
- Genomic insights into bamboo witches' broom disease: pathogenicity and phytohormone biosynthesis inFrontiers in microbiology · 2024Article
- Single amino acid change alters specificity of the multi-allelic wheat stem rust resistance locus SR9.Nature communications · 2023Article
- Resistance that stacks up: engineering rust and mildew disease control in the cereal crops wheat and barley.Plant biotechnology journal · 2023Review
- A pathogen-induced putative NAC transcription factor mediates leaf rust resistance in barley.Nature communications · 2023Article
- Sequencing trait-associated mutations to clone wheat rust-resistance gene YrNAM.Nature communications · 2023Article
- Characterization of Leaf Rust Resistance in International Barley Germplasm Using Genome-Wide Association Studies.Plants (Basel, Switzerland) · 2023Article
- Unmasking the invaders: NLR-mal function in plant defense.Frontiers in plant science · 2023Review
- HvNCX, a prime candidate gene for the novel qualitative locus qS7.1 associated with salinity tolerance in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leaf rust, caused by Puccinia hordei, is a devastating fungal disease affecting barley (Hordeum vulgare subsp. vulgare) production globally. Despite the effectiveness of genetic resistance, the deployment of single genes often compromises durability due to the emergence of virulent P. hordei races, prompting the search for new sources of resistance. Here we report on the cloning of Rph15, a resistance gene derived from barley's wild progenitor H. vulgare subsp. spontaneum. We demonstrate using introgression mapping, mutation and complementation that the Rph15 gene from the near-isogenic line (NIL) Bowman + Rph15 (referred to as BW719) encodes a coiled-coil nucleotide-binding leucine-rich repeat (NLR) protein with an integrated Zinc finger BED (ZF-BED) domain. A predicted KASP marker was developed and validated across a collection of Australian cultivars and a series of introgression lines in the Bowman background known to carry the Rph15 resistance. Rph16 from HS-680, another wild barley derived leaf rust resistance gene, was previously mapped to the same genomic region on chromosome 2H and was assumed to be allelic with Rph15 based on genetic studies. Both sequence analysis, race specificity and the identification of a knockout mutant in the HS-680 background suggest that Rph15- and Rph16-mediated resistances are in fact the same and not allelic as previously thought. The cloning of Rph15 now permits efficient gene deployment and the production of resistance gene cassettes for sustained leaf rust control.
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