Evidence map›Paper›PMID 33415794›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes.

Nada Farag, Rosanna Mattossovich, Rosa Merlo, Łukasz Nierzwicki, Giulia Palermo, Alessandro Porchetta, Giuseppe Perugino, Francesco Ricci

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Applications of triplex DNA nanostructures in sensor development.Analytical and bioanalytical chemistry · 2022
    Review
  9. First thermostable CLIP-Computational and structural biotechnology journal · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nada FaragDepartment of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.
Rosanna MattossovichInstitute of Biosciences and BioResources, National Research Council of Italy, Via Pietro Castellino 111, 80131, Naples, Italy.ORCID 0000-0002-3825-0705
Rosa MerloInstitute of Biosciences and BioResources, National Research Council of Italy, Via Pietro Castellino 111, 80131, Naples, Italy.ORCID 0000-0001-8400-193X
Łukasz NierzwickiDepartment of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA, 52512, USA.ORCID 0000-0001-9221-8848
Giulia PalermoDepartment of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA, 52512, USA.ORCID 0000-0003-1404-8737
Alessandro PorchettaDepartment of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.ORCID 0000-0002-4061-5574
Giuseppe PeruginoInstitute of Biosciences and BioResources, National Research Council of Italy, Via Pietro Castellino 111, 80131, Naples, Italy.ORCID 0000-0003-3266-4744
Francesco RicciDepartment of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.ORCID 0000-0003-4941-8646
Institute of Biosciences and Bioresources · ITUniversity of Rome Tor Vergata · ITUniversity of California, Riverside · US

Funding

Discovery of Biomarkers for Age-Related Macular DegenerationR01EY027440 · NEI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI VULLEV, VALENTINE · 2017 to 2020
$1.5M
National Institute of Health under Grant R01-EY027440NEI NIH HHS R01 EY027440
6 · The paper itself

Abstract

We present a new class of DNA-based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding-upon-repair DNA nanoswitches are synthetic DNA sequences containing O

Indexed as

NanotechnologyDNADNA RepairHumansMolecular Dynamics SimulationNucleic Acid ConformationO(6)-Methylguanine-DNA MethyltransferaseDNAO(6)-Methylguanine-DNA Methyltransferaseconformational change mechanismDNA nanoswitchesDNA nanotechnologyDNA repair enzymestriplex DNA

Identifiers

PMID33415794
PMCPMC8783695
OpenAlexW3119219133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.