Evidence map›Paper›PMID 33415771›Full record

ArticleNMR in biomedicine2021

Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.

Fayyaz Ahamed, Mark Van Criekinge, Zhen J Wang, John Kurhanewicz, Peder Larson, Renuka Sriram

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fayyaz AhamedUniversity of California, Berkeley, Berkeley, California, USA.
Mark Van CriekingeRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Zhen J WangRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-2065-5296
John KurhanewiczRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Peder LarsonRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-4183-3634
Renuka SriramRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-3505-2479
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Preclinical imaging characterization and resource development of PDX SCNC prostate cancer murine modelsU24CA253377 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, PEEHL, DONNA M. · 2020 to 2024
$3.4M
NCI NIH HHS U24 CA253377NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

Determining the aggressiveness of renal cell carcinoma (RCC) noninvasively is a critical part of the diagnostic workup for treating this disease that kills more than 15,000 people annually in the USA. Recently, we have shown that not only the amount of lactate produced, as a consequence of the Warburg effect, but also its efflux out of the cell, is a critical marker of RCC aggressiveness and differentiating RCCs from benign renal tumors. Enzymatic conversions can now be measured in situ with hyperpolarized (HP)

Indexed as

Models, BiologicalSignal Processing, Computer-AssistedAlginatesAnimalsBioreactorsCarcinoma, Renal CellCell Line, TumorHumansKidney NeoplasmsKineticsLactic AcidMiceMicrospheresMicrotechnologyModels, AnimalPerfusionAlginatesLactic AcidPyruvic Acidaerobic glycolysis, cancer aggressiveness, dynamic nuclear polarization, hyperpolarized 13C magnetic resonance, lactate, lactate efflux, modeling, pyruvate, renal cell carcinoma

Identifiers

PMID33415771
PMCPMC8423093
OpenAlexW3119756365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.