Evidence map›Paper›PMID 33415686›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2021

Blocking the Spinal Fbxo3/CARM1/K

Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Hsueh-Hsiao Wang, Po-Sheng Yang, Jen-Kun Cheng, Gin-Den Chen, Soo-Cheen Ng, An-Sheng Lee, Kuang-Wen Tseng and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. The Role of Methylation Modification in Neural Injury and Repair.International journal of molecular sciences · 2025
    Review
  3. Article
  4. The Epigenetics of Neuropathic Pain: A Systematic Update.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ming-Chun HsiehDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Yu-Cheng HoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung City, Taiwan.
Cheng-Yuan LaiDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Hsueh-Hsiao WangDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Po-Sheng YangDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Jen-Kun ChengDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Gin-Den ChenDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan.
Soo-Cheen NgDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan.
An-Sheng LeeDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Kuang-Wen TsengDepartment of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan.
Tzer-Bin Lin *Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Hsien-Yu Peng *Department of Medicine, Mackay Medical College, No.46, Sec. 3, Zhongzheng Rd, Sanzhi Dist, New Taipei, 25245, Taiwan. hsien.yu@gmail.com.
Mackay Medical College · TWChung Shan Medical University Hospital · TWMackay Memorial Hospital · TWAsia University · TWI-Shou University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many epigenetic regulators are involved in pain-associated spinal plasticity. Coactivator-associated arginine methyltransferase 1 (CARM1), an epigenetic regulator of histone arginine methylation, is a highly interesting target in neuroplasticity. However, its potential contribution to spinal plasticity-associated neuropathic pain development remains poorly explored. Here, we report that nerve injury decreased the expression of spinal CARM1 and induced allodynia. Moreover, decreasing spinal CARM1 expression by Fbxo3-mediated CARM1 ubiquitination promoted H3R17me2 decrement at the K

Indexed as

Potassium ChannelsAnimalsEpigenesis, GeneticF-Box ProteinsFemaleMaleNeuralgiaPain ManagementProtein-Arginine N-MethyltransferasesRatsRats, Sprague-DawleyRNA, Small InterferingSpinal CordSpinal Cord Dorsal Horncoactivator-associated arginine methyltransferase 1F-box protein 3, ratF-Box ProteinsPotassium ChannelsProtein-Arginine N-MethyltransferasesRNA, Small InterferingCARM1Fbxo3Histone arginine methylationneuropathic painspinal

Identifiers

PMID33415686
PMCPMC8423947
OpenAlexW3118822360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.