Evidence map›Paper›PMID 33415679›Full record

ReviewMolecular imaging and biology2021

Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy.

Changhua Mu, David E Korenchan, Sinan Wang, David M Wilson, Robert R Flavell

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Hyperpolarized [1-Molecular imaging and biology · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Changhua MuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
David E KorenchanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Sinan WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Robert.flavell@ucsf.edu.ORCID 0000-0002-8694-1199
University of California, San Francisco · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Application of hyperpolarized 13C interstitial pH imaging to risk stratification in prostate cancerR21EB026012 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLAVELL, ROBERT RICHARD · 2018 to 2020
$503k
NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R21 EB026012
6 · The paper itself

Abstract

Hyperpolarization (HP) of a carbon-13 molecule via dynamic nuclear polarization (DNP) involves polarization at low temperature, followed by a dissolution procedure producing a solution with highly polarized spins at room temperature. This dissolution DNP method significantly increases the signal-to-noise ratio (SNR) of nuclear magnetic resonance (NMR) over 10,000-fold and facilitates the use of magnetic resonance spectroscopy (MRS) to image not only metabolism but also the extracellular microenvironment. The extracellular tumor microenvironment (TME) closely interacts with tumor cells and stimulates their growth and metastasis. Thus, the ability to detect pathological changes in the TME is pivotal for the detection and study of cancers. This review highlights the potential use of MRS to study features of the TME-elevated export of lactate, reduced interstitial pH, imbalanced redox equilibrium, and altered metal homeostasis. The promising outcomes of both in vitro and in vivo assays suggest that DNP-MRS may be a useful technique to study aspects of the TME. With continued improvements, this tool has the potential to study the TME and provide guidance for accurate patient stratification and precise personal therapy. Graphical Abstract.

Indexed as

Biosensing TechniquesCarbon-13 Magnetic Resonance SpectroscopyTumor MicroenvironmentAnimalsCarbon IsotopesCold TemperatureHumansLactic AcidMagnetic Resonance SpectroscopyMiceNeoplasm InvasivenessNeoplasm MetastasisRatsSignal-To-Noise RatioCarbon-13Carbon IsotopesLactic AcidBiosensorsCarbon-13 cellular substratesDynamic nuclear polarizationHyperpolarizationMagnetic resonance spectroscopyTumor microenvironment

Identifiers

PMID33415679
PMCPMC8105261
OpenAlexW3120894965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.