ArticlePediatric nephrology (Berlin, Germany)2021
Low agreement between kidney volume and kidney length z-scores.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Model to Define Reference Ultrasound Parameters for Early Assessment of Nephron Endowment in Extremely Low Birth Weight Preterm Infants.Children (Basel, Switzerland) · 2026Article
- Kidney volume normative values in Central European children aged 0-19 years: a multicenter study.Pediatric nephrology (Berlin, Germany) · 2024Article
- Body surface area-based kidney length percentiles misdiagnose small kidneys in children with overweight/obesity.Pediatric nephrology (Berlin, Germany) · 2023Article
- What to do with kidney length and volumes in large individuals?Pediatric nephrology (Berlin, Germany) · 2023Article
- Editorial: There Is Still a Need for Kidney Volume Reference Intervals in Large Children, Adolescents, and Young Adults.Canadian journal of kidney health and disease · 2023Article
- Low Birthweight as a Risk Factor for Non-communicable Diseases in Adults.Frontiers in medicine · 2021Review
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Authors and funding
6 authors.
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Abstract
backgroundPediatric nephrologists use kidney length and kidney volume z-scores to longitudinally assess normal nephron endowment. However, most radiologists only report kidney length. Agreement between kidney length and kidney volume z-scores in children has been understudied. This study aims to assess agreement between kidney length and kidney volume z-scores in children.
methodsThis novel cross-sectional cohort study prospectively followed prematurely born babies from a large specialized prematurity follow-up center. A healthy control group matched the cases by age and sex and was recruited from schools. Children were assessed for kidney length and kidney volumes at age 5 by three independent ultrasonographers. All measurements were performed in triplicate. Detailed anthropometry, blood pressure, and kidney function were also obtained. Age-independent z-scores were calculated for all parameters according to Scholbach and Weitzel and compared using descriptive statistics.
resultsWe studied 89 premature patients (median 32 weeks gestational age) and 33 healthy controls (median 38 weeks gestational age). There were 732 determinations of kidney length, width, and thickness. The mean z-score of the right kidney length was 0.65 ± 0.08 (SEM) compared with 0.88 ± 0.08 of the left kidney length (p = 0.0003, two-sided paired t test). The squared correlation coefficient for kidney volume to kidney length was 0.32 (p < 0.0001). Bland and Altman analysis revealed considerable bias with - 1.36 ± 0.76 standard deviations and 95% limits of agreement from - 2.83 to - 0.16.
conclusionReporting only kidney length results in significant overestimation of age-independent z-scores. Based on our findings, consideration to measuring all kidney dimensions may be more appropriate.
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