Evidence map›Paper›PMID 33415453›Full record

ArticleClinical rheumatology2022

Serum level of fetuin-A in systemic lupus erythematosus patients: association with atherosclerosis and disease activity.

Doaa Salah Atta, Ahmed Emera, Rana S Ghoneim, Amina M Elnaggar

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Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Doaa Salah AttaRheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. doaa.sa@hotmail.com.
Ahmed EmeraRheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Rana S GhoneimRheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Amina M ElnaggarClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed in this study to determine the level of serum fetuin-A level in systemic lupus erythematosus patients, assess the correlation between serum fetuin-A level and the activity of disease and the frequency of musculoskeletal manifestations, and detect the frequency of atherosclerosis among these patients by using carotid ultrasonography.

methodsThis case-control study was carried out on 31 SLE patients attending the inpatient and outpatient clinics of Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig university hospitals and 31 apparently healthy age- and sex-matched controls between January 1,2017, and December 31, 2018.

resultsThere is a highly significant difference between the two studied groups as regard fetuin-A and carotid intima-media thickness. There is a strong positive significant correlation between fetuin-A with C3 and a negative significant correlation between fetuin-A with Anti-dsDNA, SLEDAI, and carotid intima-media thickness in case group.

conclusionFetuin-A levels were decreased in SLE patients, and these levels were inversely correlated with carotid intima-media thickness. Key Points • Fetuin-A level is a biomarker of atherosclerosis and asses disease activity in SLE patients.

Indexed as

AtherosclerosisLupus Erythematosus, Systemicalpha-2-HS-GlycoproteinCarotid Intima-Media ThicknessCase-Control StudiesHumansRisk Factorsalpha-2-HS-GlycoproteinAtherosclerosisFetuin-ASLE

Identifiers

PMID33415453
OpenAlexW3120206444

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.