Evidence map›Paper›PMID 33415322›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2020

Fisher-Rao Regularized Transport Analysis of the Glymphatic System and Waste Drainage.

Rena Elkin, Saad Nadeem, Hedok Lee, Helene Benveniste, Allen Tannenbaum

Abstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Fluid transport in the brain.Physiological reviews · 2022
    Review
  2. Waste Clearance in the Brain.Frontiers in neuroanatomy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rena ElkinDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York NY 10065, USA.
Saad NadeemDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York NY 10065, USA.
Hedok LeeDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT 06519, USA.
Helene BenvenisteDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT 06519, USA.
Allen TannenbaumDepartments of Computer Science and Applied Mathematics & Statistics, Stony Brook University, Stony Brook, NY 11794, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Supplement for Kennelia MellansonRF1AG057705 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI BENVENISTE, HELENE D, ENIKOLOPOV, GRIGORI N · 2017 to 2021
$3.7M
Characterizing the glymphatic peri-vascular connectome and its disruption in ADRF1AG053991 · NIA · YALE UNIVERSITY · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2016 to 2016
$3.4M
Glymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NIA NIH HHS R01 AG048769NIA NIH HHS RF1 AG053991NIA NIH HHS RF1 AG057705
6 · The paper itself

Abstract

In this work, a unified representation of all the time-varying dynamics is accomplished with a Lagrangian framework for analyzing Fisher-Rao regularized dynamical optimal mass transport (OMT) derived flows. While formally equivalent to the Eulerian based Schrödinger bridge OMT regularization scheme, the Fisher-Rao approach allows a simple and interpretable methodology for studying the flows of interest in the present work. The advantage of the proposed Lagrangian technique is that the time-varying particle trajectories and attributes are displayed in a single visualization. This provides a natural capability to identify and distinguish flows under different conditions. The Lagrangian analysis applied to the glymphatic system (brain waste removal pathway associated with Alzheimer's Disease) successfully captures known flows and distinguishes between flow patterns under two different anesthetics, providing deeper insights into altered states of waste drainage.

Indexed as

Fisher-Rao regularizationGlymphatic systemOptimal mass transport

Identifiers

PMID33415322
PMCPMC7787169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.