Evidence map›Paper›PMID 33415211›Full record

ReviewSAGE open nursing

Prevalence, Burden, and Treatment of Lower Urinary Tract Symptoms in Men Aged 50 and Older: A Systematic Review of the Literature.

Amy Y Zhang, Xinyi Xu

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in SAGE open nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07056192 narecruitingnot on this map

Impact of Verbal Compared to Structured Information on Patient's Anxiety and Satisfaction Undergoing Uroflowmetry

TypeinterventionalSponsorAga Khan University Hospital, PakistanRan2025 to 2025Enrolled132ConditionsAnxiety, SatisfactionArmsStructured education group
NCT07663344 nanot yet recruitingnot on this map

Prospective Feasibility Trial on MRI-TRUS Fusion Water Vapour Ablation for Benign Prostatic Hyperplasia (STEAM-MAP 1 Study - Steam Therapy With MRI and AI-assisted Planning)

TypeinterventionalSponsorChinese University of Hong KongRan2026 to 2028Enrolled15ConditionsBenign Prostatic Hyperplasia (BPH)ArmsMRI-TRUS fusion-guided Rezūm therapy
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy and Safety ofNutrients · 2026
    Trial
  4. Article
  5. Article
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  7. bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Macrophages and TGFB signaling regulate fibrosis in theAmerican journal of physiology. Renal physiology · 2026
    Article
  11. Article
  12. Observational
  13. Impact of surgical bladder catheter implantation on voiding function in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Amy Y ZhangFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Xinyi XuUniversity Hospitals Cleveland Medical Center Seidman Cancer Center, Cleveland, OH, USA.
Case Western Reserve University · USUniversity Hospitals Seidman Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a systematic review of literature from the years 2000 through 2017 on the prevalence and burden of lower urinary tract symptoms (LUTS) in men aged 50 and older, and medical treatments of and alternative nonmedical approaches to LUTS. EBSCOhost (Medline with Full Text) was searched for observational, experimental, and review studies in peer-reviewed journals in the English language. Our review found that LUTS were highly prevalent in the world and estimated to affect 2.3 billion people in 2018, with 44.7% being men. Men with LUTS suffer from not only burdensome symptoms such as nocturia and urgency but also adverse psychological consequences (e.g., anxiety and depression) and financial burden. Current medical treatments are clinically effective, but their efficacy is compromised by side effects and low compliance rates. Alternative nonmedical treatments for LUTS were also sought worldwide. There is evidence that lifestyle modifications such as pelvic muscle exercises and bladder training, physical activity, dietary modification, and nutritional supplements can alleviate LUTS and improve patient quality of life; however, evidence based on rigorous methodology remains minimal and cannot be generalized across populations. Evidence of effectiveness of weight loss programs to reduce LUTS is inconclusive. We conclude that although behavioral treatment is a promising approach to alleviating LUTS, especially when combined with medical treatments, well-designed randomized controlled and longitudinal clinical trials on behavioral treatments of LUTS are still needed. Minimally invasive procedures and neuromodulation therapy also show positive results of alleviating LUTS but require further research as well.

Indexed as

behavioral interventionlower urinary tract symptomsLUTS burdenLUTS prevalenceQOL

Identifiers

PMID33415211
PMCPMC7774430
OpenAlexW2908295281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.