Evidence map›Paper›PMID 33415184›Full record

ArticleAdvanced therapeutics2020

Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA-Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines.

Sukumar Uday Kumar, Arsenii V Telichko, Huaijun Wang, Dongwoon Hyun, Eric G Johnson, Michael S Kent, Robert B Rebhun, Jeremy J Dahl, William T N Culp, Ramasamy Paulmurugan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sukumar Uday KumarMolecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California; Department of Radiology, Stanford University, Stanford, California.
Arsenii V TelichkoMolecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California; Department of Radiology, Stanford University, Stanford, California.
Huaijun WangMolecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California; Department of Radiology, Stanford University, Stanford, California.
Dongwoon HyunMolecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California; Department of Radiology, Stanford University, Stanford, California.
Eric G JohnsonDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.
Michael S KentDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.
Robert B RebhunDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.
Jeremy J DahlMolecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California; Department of Radiology, Stanford University, Stanford, California.
William T N CulpDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.
Ramasamy PaulmuruganMolecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California; Department of Radiology, Stanford University, Stanford, California.

Funding

Therapeutic miRNA Modulation of Hepatocellular Carcinoma Using Ultrasound Guided Drug DeliveryR01CA209888 · NCI · STANFORD UNIVERSITY · PI DAHL, JEREMY, PAULMURUGAN, RAMASAMY · 2017 to 2021
$3.1M
3D Passive Cavitation Imaging-Guided Therapeutic Delivery of MicroRNA into CancerR21EB022298 · NIBIB · STANFORD UNIVERSITY · PI PAULMURUGAN, RAMASAMY · 2016 to 2017
$441k
Celigo S Imaging Cytometer (200-BFFL-S)S10OD023518 · OD · STANFORD UNIVERSITY · PI PAULMURUGAN, RAMASAMY · 2018 to 2018
$174k
NCI NIH HHS R01 CA209888NIBIB NIH HHS R21 EB022298NIH HHS S10 OD023518
6 · The paper itself

Abstract

Spatially localized microbubble cavitation by ultrasound offers an effective means of altering permeability of natural barriers (i.e. blood vessel and cell membrane) in favor of nanomaterials accumulation in the target site. In this study, a clinically relevant, minimally invasive ultrasound guided therapeutic approach is investigated for targeted delivery of anticancer microRNA loaded PLGA-

Indexed as

dog modelfocused ultrasoundmicrobubblesmicroRNAmicroRNA deliverynanoparticlestargeted delivery

Identifiers

PMID33415184
PMCPMC7784952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.