Evidence map›Paper›PMID 33415098›Full record

ArticleFrontiers in chemistry2020

Interleukin-1 Receptor Modulation Using β-Substituted α-Amino-γ-Lactam Peptides From Solid-Phase Synthesis and Diversification.

Azade Geranurimi, Colin W H Cheng, Christiane Quiniou, France Côté, Xin Hou, Isabelle Lahaie, Amarilys Boudreault, Sylvain Chemtob, William D Lubell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Azade GeranurimiDépartement de Chimie, Université de Montréal, Montréal, QC, Canada.
Colin W H ChengDepartment of Pharmacology & Therapeutics, McGill University, Montréal, QC, Canada.
Christiane QuiniouHôpital Sainte-Justine Research Centre, Montréal, QC, Canada.
France CôtéDepartment of Pharmacology & Therapeutics, McGill University, Montréal, QC, Canada.
Xin HouHôpital Sainte-Justine Research Centre, Montréal, QC, Canada.
Isabelle LahaieHôpital Sainte-Justine Research Centre, Montréal, QC, Canada.
Amarilys BoudreaultHôpital Sainte-Justine Research Centre, Montréal, QC, Canada.
Sylvain ChemtobDepartment of Pharmacology & Therapeutics, McGill University, Montréal, QC, Canada.
William D LubellDépartement de Chimie, Université de Montréal, Montréal, QC, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CAUniversité de Montréal · CAMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a key cytokine mediator of inflammation, interleukin-1β (IL-1β) binds to the IL-1 receptor (IL-1R) and activates various downstream signaling mediators, including NF-κB, which is required for immune vigilance and cellular protection. Toward the development of IL-1-targeting therapeutics which exhibit functional selectivity, the all-D-amino acid peptide

Indexed as

allosteric modulationbiased signalinginterleukin-1lactampreterm (birth)retinopathysolid-phase peptide synthesisβ-turn

Identifiers

PMID33415098
PMCPMC7783595
OpenAlexW3116034222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.