ArticleSultan Qaboos University medical journal2020
Acute Kidney Injuries in Children with Severe Malaria: A comparative study of diagnostic criteria based on serum cystatin C and creatinine levels.
Article in Sultan Qaboos University medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review.Malaria journal · 2026Pooled it
- Incidence of acute kidney injury and associated mortality in Nigeria: systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Immunomodulation Therapy to Treat Severe Malaria With Multiple Organ Failure.Critical care explorations · 2026Article
- Article
- Prevalence of acute kidney injury and its associated factors among malaria patients admitted to public hospitals in the Ilu Aba Bora and Bedelle Zones of Oromia region, Southwest Ethiopia.BMC infectious diseases · 2026Article
- Identification of acute kidney injury in African children with severe malaria: a multinational individual participant data meta-analysis.Research square · 2025Article
- Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria.BMC nephrology · 2025Article
- Novel acute kidney injury biomarkers and their utility in children and adolescents-overview.Italian journal of pediatrics · 2025Review
- Animal Models of Malaria-Associated Acute Kidney Injury.Seminars in nephrology · 2025Review
- The kidney-brain pathogenic axis in severe falciparum malaria.Trends in parasitology · 2023Review
- Acute Kidney Injury Interacts With Coma, Acidosis, and Impaired Perfusion to Significantly Increase Risk of Death in Children With Severe Malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2022Article
- Pathophysiology of Acute Kidney Injury in Malaria and Non-Malarial Febrile Illness: A Prospective Cohort Study.Pathogens (Basel, Switzerland) · 2022Article
- Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges.International journal of nephrology and renovascular disease · 2021Review
- Immunopathology of Acute Kidney Injury in Severe Malaria.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSerum creatinine levels are often used to diagnose acute kidney injury (AKI), but may not necessarily accurately reflect changes in glomerular filtration rate (GFR). This study aimed to compare the prevalence of AKI in children with severe malaria using diagnostic criteria based on creatinine values in contrast to cystatin C.
methodsThis prospective cross-sectional study was performed between June 2016 and May 2017 at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. A total of 170 children aged 0.5-14 years old with severe malaria were included. Serum cystatin C levels were determined using a particle-enhanced immunoturbidmetric assay method, while creatinine levels were measured using the Jaffe reaction. Renal function assessed using cystatin C-derived estimated GFR (eGFR) was compared to that measured using three sets of criteria based on creatinine values including the Kidney Disease: Improved Global Outcomes (KDIGO) and World Health Organization (WHO) criteria as well as an absolute creatinine cut-off value of >1.5 mg/dL.
resultsMean serum cystatin C and creatinine levels were 1.77 ± 1.37 mg/L and 1.23 ± 1.80 mg/dL, respectively (
conclusionDiagnostic criteria for AKI based on creatinine values may not indicate the actual burden of disease in children with severe malaria.
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