Evidence map›Paper›PMID 33414903›Full record

ArticleJournal of tissue engineering

Decellularized pulp matrix as scaffold for mesenchymal stem cell mediated bone regeneration.

Dong Joon Lee, Patricia Miguez, Jane Kwon, Renie Daniel, Ricardo Padilla, Samuel Min, Rahim Zalal, Ching-Chang Ko, Hae Won Shin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dong Joon LeeOral and Craniofacial Health Science Institute, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-9284-0773
Patricia MiguezOral and Craniofacial Health Science Institute, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Jane KwonOral and Craniofacial Health Science Institute, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Renie DanielDepartment of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Ricardo PadillaDepartment of Diagnostic Sciences, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Samuel MinOral and Craniofacial Health Science Institute, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Rahim ZalalOral and Craniofacial Health Science Institute, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Ching-Chang KoDepartment of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Hae Won ShinDepartment of Neurology and Neurosurgery, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0001-6400-6100
University of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scaffolds that are used for bone repair should provide an adequate environment for biomineralization by mesenchymal stem cells (MSCs). Recently, decellularized pulp matrices (DPM) have been utilized in endodontics for their high regenerative potential. Inspired by the dystrophic calcification on the pulp matrix known as pulp stone, we developed acellular pulp bioscaffolds and examined their potential in facilitating MSCs mineralization for bone defect repair. Pulp was decellularized, then retention of its structural integrity was confirmed by histological, mechanical, and biochemical evaluations. MSCs were seeded and proliferation, osteogenic gene expression, and biomineralization were assessed to verify DPM's osteogenic effects in vitro. MicroCT, energy-dispersive X-ray (EDX), and histological analyses were used to confirm that DPM seeded with MSCs result in greater mineralization on rat critical-sized defects than that without MSCs. Overall, our study proves DPM's potential to serve as a scaffolding material for MSC-mediated bone regeneration for future craniofacial bone tissue engineering.

Indexed as

biomineralizationcritical sized defectDecellularized pulp matrixdystrophic calcificationmesenchymal stem cells

Identifiers

PMID33414903
PMCPMC7750895
OpenAlexW3112150112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.